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Role of Adjuvant Treatment in High-risk Patients Following Resection for Gallbladder Cancer
- Title
- Role of Adjuvant Treatment in High-risk Patients Following Resection for Gallbladder Cancer
- Authors
- Park Y.; Kim K.; Park H.J.; Chun H.-J.; Choi D.
- Ewha Authors
- 김규보
- SCOPUS Author ID
- 김규보
- Issue Date
- 2022
- Journal Title
- In Vivo
- ISSN
- 0258-851X
- Citation
- In Vivo vol. 36, no. 2, pp. 961 - 968
- Keywords
- adjuvant chemotherapy; adjuvant radiotherapy; adjuvant treatment; Gallbladder cancer; prognostic factor
- Publisher
- International Institute of Anticancer Research
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Aim: To identify prognostic factors for surgically resected gallbladder cancer (GBC). Patients and Methods: Medical records of 66 patients with GBC undergoing potentially curative resection between 2001 and 2017 were retrospectively reviewed. Results: After a median follow-up of 39.9 months (range=0.5-216.4 months), 22 locoregional recurrences and 25 distant metastases occurred. Adjuvant radiotherapy and adjuvant chemotherapy failed to prove efficacy in all patient groups. In patients with stage III-IV GBC, adjuvant chemotherapy showed a marginally positive effect on locoregional control (p=0.064), and was significantly beneficial for overall survival (p=0.040), and adjuvant treatment improved both locoregional control and overall survival (p=0.029 and p=0.005, respectively). On multivariate analysis, a negative resection margin was a significant prognostic factor for superior local control, and disease-free and overall survival (p=0.003, p=0.010 and p=0.005, respectively) and adjuvant treatment was associated with improved overall survival (p=0.018). Conclusion: Adjuvant treatment is recommended for patients with stage III-IV GBC following curative surgical resection. © 2022 International Institute of Anticancer Research. All rights reserved.
- DOI
- 10.21873/INVIVO.12787
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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