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18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment
- Title
- 18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment
- Authors
- Chun M.Y.; Lee J.; Jeong J.H.; Roh J.H.; Oh S.J.; Oh M.; Oh J.S.; Kim J.S.; Moon S.H.; Woo S.-Y.; Kim Y.J.; Choe Y.S.; Kim H.J.; Na D.L.; Jang H.; Seo S.W.
- Ewha Authors
- 정지향
- SCOPUS Author ID
- 정지향
- Issue Date
- 2022
- Journal Title
- Yonsei Medical Journal
- ISSN
- 0513-5796
- Citation
- Yonsei Medical Journal vol. 63, no. 3, pp. 259 - 264
- Keywords
- Amyloid; Inflammation; Mild cognitive impairment; Tau proteins; Positron emission tomography
- Publisher
- Yonsei University College of Medicine
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Purpose: Neuroinflammation is considered an important pathway associated with several diseases that result in cognitive decline.18F-THK5351 positron emission tomography (PET) signals might indicate the presence of neuroinflammation, as well as Alzheimer’s disease-type tau aggregates. β-amyloid (Aβ)-negative (Aβ–) amnestic mild cognitive impairment (aMCI) may be associated with non-Alzheimer’s disease pathophysiology. Accordingly, we investigated associations between18F-THK5351 PET positivity and cognitive decline among Aβ– aMCI patients. Materials and Methods: The present study included 25 amyloid PET negative aMCI patients who underwent a minimum of two follow-up neuropsychological evaluations, including clinical dementia rating-sum of boxes (CDR-SOB). The patients were classified into two groups:18F-THK5351-positive and-negative groups. The present study used a linear mixed effects model to estimate the effects of18F-THK5351 PET positivity on cognitive prognosis among Aβ– aMCI patients. Results: Among the 25 Aβ– aMCI patients, 10 (40.0%) were18F-THK5351 positive. The patients in the18F-THK5351-positive group were older than those in the18F-THK5351-negative group (77.4±2.2 years vs. 70.0±5.5 years; p<0.001). There was no difference between the two groups with regard to the proportion of apolipoprotein E ε4 carriers. Interestingly, however, the CDR-SOB scores of the18F-THK5351-positive group deteriorated at a faster rate than those of the18F-THK5351-negative group (B=0.003, p=0.033). Conclusion: The results of the present study suggest that increased18F-THK5351 uptake might be a useful predictor of poor prognosis among Aβ– aMCI patients, which might be associated with increased neuroinflammation (ClinicalTrials.gov NCT02656498). © Yonsei University College of Medicine 2022.
- DOI
- 10.3349/ymj.2022.63.3.259
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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