Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김규보 | * |
dc.date.accessioned | 2022-03-29T16:31:03Z | - |
dc.date.available | 2022-03-29T16:31:03Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 2234-943X | * |
dc.identifier.other | OAK-31117 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260943 | - |
dc.description.abstract | Background: To evaluate the prognostic value of neutrophil-lymphocyte ratio (NLR) in rectal cancer patients treated with preoperative chemoradiotherapy (CRT) and curative surgery. Methods: A comprehensive search of the EMBASE and PubMed databases was performed to screen studies that compared treatment outcomes according to the pre-CRT and/or post-CRT NLR in patients receiving preoperative CRT and curative surgery for locally advanced rectal cancer. Hazard ratios (HRs) for disease-free survival (DFS) and/or overall survival (OS) were extracted, and a random-effects model was used for pooled analysis. Results: Totally, 22 retrospective studies comprising 6316 patients were included. Preoperative CRT was administered with concurrent chemotherapy (mostly fluoropyrimidine-based regimens). The elevated pre-CRT NLR was significantly associated with an increased risk of recurrence (HR, 1.54; 95% confidence interval [CI], 1.31-1.81) and death (HR, 2.14; 95% CI, 1.61-2.84). Post-CRT NLR was reported in only 3 of 22 studies, and the correlation was not statistically significant for recurrence (HR, 1.44; 95% CI, 0.86-2.41) or death (HR, 2.38; 95% CI, 0.94-6.07). Conclusions: Elevated pre-CRT NRL, but not post-CRT NRL, is associated with inferior DFS and OS. Further studies are needed to confirm the prognostic value of NLR in rectal cancer patients receiving preoperative CRT. Copyright © 2022 Lee, Kim and Park. | * |
dc.language | English | * |
dc.publisher | Frontiers Media S.A. | * |
dc.subject | chemoradiotherapy | * |
dc.subject | meta-analysis | * |
dc.subject | neutrophil-lymphocyte ratio | * |
dc.subject | radiotherapy | * |
dc.subject | rectal cancer | * |
dc.title | Meta-Analysis on the Neutrophil-Lymphocyte Ratio in Rectal Cancer Treated With Preoperative Chemoradiotherapy: Prognostic Value of Pre- and Post-Chemoradiotherapy Neutrophil-Lymphocyte Ratio | * |
dc.type | Review | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Frontiers in Oncology | * |
dc.identifier.doi | 10.3389/fonc.2022.778607 | * |
dc.identifier.wosid | WOS:000761600300001 | * |
dc.identifier.scopusid | 2-s2.0-85125341028 | * |
dc.author.google | Lee S.J. | * |
dc.author.google | Kim K. | * |
dc.author.google | Park H.J. | * |
dc.contributor.scopusid | 김규보(8213302900) | * |
dc.date.modifydate | 20240222162403 | * |