Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이현국 | * |
dc.date.accessioned | 2022-03-29T16:30:57Z | - |
dc.date.available | 2022-03-29T16:30:57Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 2072-6694 | * |
dc.identifier.other | OAK-31151 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260911 | - |
dc.description.abstract | Several treatment guidelines for sporadic, nonmetastatic nonfunctioning neuroendocrine tumors of the pancreas (NF-pNETs) have recommended resection, however, tumors ≤ 2 cm do not necessarily need surgery. This study aims to establish a surgical treatment plan for NF-pNETs ≤ 2 cm. From 2000 to 2017, 483 patients who underwent resection for NF-pNETs ≤ 2 cm in 18 institutions from Korea and China were enrolled and their medical records were reviewed. The median age was 56 (range 16–80) years. The 10-year overall survival rate (10Y-OS) and recurrence-free survival rate (10Y-RFS) were 89.8 and 93.1%, respectively. In multivariable analysis, tumor size (>1.5 cm; HR 4.28, 95% CI 1.80–10.18, p = 0.001) and nodal metastasis (HR 3.32, 95% CI 1.29–8.50, p = 0.013) were independent adverse prognostic factors for OS. Perineural invasion (HR 4.36, 95% CI 1.48–12.87, p = 0.008) and high Ki-67 index (≥3%; HR 9.06, 95% CI 3.01–27.30, p < 0.001) were independent prognostic factors for poor RFS. NF-pNETs ≤ 2 cm showed unfavorable prognosis after resection when the tumor was larger than 1.5 cm, Ki-67 index ≥ 3%, or nodal metastasis was present. NF-pNET patients with tumors ≤ 1.5 cm can be observed if the preoperative Ki-67 index is under 3%, and if nodal metastasis is not suspected in preoperative radiologic studies. These findings support the clinical use to make decisions about small NF-pNETs. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | Nonfunctioning neuroendocrine tumor of pancreas | * |
dc.subject | Prognosis | * |
dc.subject | Resection | * |
dc.subject | Risk factors | * |
dc.title | Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 14 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Cancers | * |
dc.identifier.doi | 10.3390/cancers14041038 | * |
dc.identifier.wosid | WOS:000767558900001 | * |
dc.identifier.scopusid | 2-s2.0-85125087909 | * |
dc.author.google | Han I.W. | * |
dc.author.google | Park J. | * |
dc.author.google | Park E.Y. | * |
dc.author.google | Yoon S.J. | * |
dc.author.google | Jin G. | * |
dc.author.google | Hwang D.W. | * |
dc.author.google | Jiang K. | * |
dc.author.google | Kwon W. | * |
dc.author.google | Xu X. | * |
dc.author.google | Heo J.S. | * |
dc.author.google | Fu D.-L. | * |
dc.author.google | Lee W.J. | * |
dc.author.google | Bai X. | * |
dc.author.google | Yoon Y.-S. | * |
dc.author.google | Yang Y.-M. | * |
dc.author.google | Ahn K.S. | * |
dc.author.google | Yuan C. | * |
dc.author.google | Lee H.K. | * |
dc.author.google | Sun B. | * |
dc.author.google | Park E.K. | * |
dc.author.google | Lee S.E. | * |
dc.author.google | Kang S. | * |
dc.author.google | Lou W. | * |
dc.author.google | Park S.-J. | * |
dc.contributor.scopusid | 이현국(8861888600) | * |
dc.date.modifydate | 20240118164806 | * |