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Revisiting glomerular hyperfiltration and examining the concept of high dietary protein-related nephropathy in athletes and bodybuilders
- Title
- Revisiting glomerular hyperfiltration and examining the concept of high dietary protein-related nephropathy in athletes and bodybuilders
- Authors
- Cho E.; Choi S.J.; Kang D.-H.; Kalantar-Zadeh K.; Ko G.-J.
- Ewha Authors
- 강덕희
- SCOPUS Author ID
- 강덕희
- Issue Date
- 2022
- Journal Title
- Current opinion in nephrology and hypertension
- ISSN
- 1473-6543
- Citation
- Current opinion in nephrology and hypertension vol. 31, no. 1, pp. 18 - 25
- Publisher
- NLM (Medline)
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- PURPOSE OF REVIEW: High-protein diets (HPDs) are popular but their consequences for kidney health, especially among athletes and bodybuilders who typically maintain a high protein intake for a long time, have not been investigated. This review focused on recent studies of the association of HPD with long-term kidney health and the concept of high dietary protein-related nephropathy. RECENT FINDINGS: Several long-term observational studies including large populations have reinforced the notion that HPDs are associated with a rapid decline of kidney function. An increase in renal blood flow and glomerular hyperfiltration caused by vasodilation, and increased levels of endocrine and paracrine factors (glucagon, IGF-1, prostanoids, and nitric oxide), facilitates the excretion of protein-derived nitrogenous waste. Inhibition of tubule-glomerular feedback and increased proximal tubular Na+ reabsorption after a HPD augment glomerular hyperfiltration and may trigger synthesis of proinflammatory cytokines and receptor for advanced glycation end-products (RAGE). Focal segmental glomerulosclerosis reported in association with anabolic steroid may indeed be a HPD nephropathy given that HPD results in progressive glomerulosclerosis, especially in remnant glomeruli or in diabetic kidney disease but can happen in any high-risk situation, such as solitary kidney and polycystic kidneys. SUMMARY: HPD among athletes and bodybuilders in an extreme way across a long-term period may pose a risk to renal health including high incidence of HPD nephropathy. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
- DOI
- 10.1097/MNH.0000000000000755
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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