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Optimal Surgical Extent in Patients with Unilateral Multifocal Papillary Thyroid Carcinoma
- Title
- Optimal Surgical Extent in Patients with Unilateral Multifocal Papillary Thyroid Carcinoma
- Authors
- Woo J.; Kwon H.
- Ewha Authors
- 권형주; 우주현
- SCOPUS Author ID
- 권형주; 우주현
- Issue Date
- 2022
- Journal Title
- Cancers
- ISSN
- 2072-6694
- Citation
- Cancers vol. 14, no. 2
- Keywords
- Lobectomy; Multifocality; Operative extent; Papillary thyroid carcinoma
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Multifocality increases the risk of recurrence in patients with papillary thyroid carcinoma (PTC); however, it is unclear whether multifocality justifies more extensive or aggressive surgical treatment. Here, we evaluated the effect of the operative extent on the recurrence-free survival (RFS) of patients with multifocal PTC. Between 2010 and 2019, 718 patients with unilateral multifocal PTC were enrolled; 115 patients (16.0%) underwent ipsilateral thyroid lobectomy, and 606 patients (84.0%) underwent total thyroidectomy. With a mean follow up of 5.2 years, RFS was comparable between the total thyroidectomy and lobectomy groups (p = 0.647) after adjusting for potential confounders. Multivariable Cox regression analysis also demonstrated that the operative extent was not an independent predictor of recurrence (HR 1.686, 95% CI: 0.321–8.852). Subgroup analyses further indicated that both total thyroidectomy and thyroid lobectomy resulted in comparable RFS for multifocal PTC patients with other high-risk factors, including tumor size > 1 cm (p = 0.711), lymph node metastasis (p = 0.536), and intermediate ATA risk of recurrence (p = 0.682). In conclusion, thyroid lobectomy was not associated with the risk of recurrence in patients with multifocal PTCs. Multifocality in PTC may not always require aggressive surgery. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
- DOI
- 10.3390/cancers14020432
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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