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공과대학
화공신소재공학과
Journal papers
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Emerging strategies for biomaterial-assisted cancer immunotherapy
Title
Emerging strategies for biomaterial-assisted cancer immunotherapy
Authors
Joo K.I.
Ewha Authors
주계일
SCOPUS Author ID
주계일
Issue Date
2022
Journal Title
Korean Journal of Chemical Engineering
ISSN
0256-1115
Citation
Korean Journal of Chemical Engineering vol. 39, no. 2, pp. 227 - 240
Keywords
Biomaterials
;
Cancer Immunotherapy
;
Combination Therapy
;
Immuno-engineering
;
Localized Delivery
Publisher
Springer
Indexed
SCIE; SCOPUS; KCI
Document Type
Review
Abstract
Among many treatment options to prevent cancer progression, cancer immunotherapy has become a powerful clinical strategy due to its favorable clinical outcomes. The number of clinical trials in immune checkpoint blockade (ICB) therapy and chimeric antigen receptor (CAR)-T cell therapy has been remarkably increasing in recent years. However, the currently available options for these treatments pose significant challenges related to immune-related adverse effects and limited therapeutic efficacy. Excellent delivery technologies by leveraging biomaterials to mitigate these limitations could potentially advance current cancer immunotherapies for a wide range of applications. In this review, we analyze various strategies of biomaterial-assisted cancer immunotherapy for localized, targeted, and combined treatments and then summarize the promises and challenges for integrating biomaterial-based delivery technologies into cancer immunotherapy. © 2022, The Korean Institute of Chemical Engineers.
DOI
10.1007/s11814-021-0985-z
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