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The Long-term Efficacy of Domiciliary Noninvasive Positive-Pressure Ventilation in Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomized Controlled Trials
- Title
- The Long-term Efficacy of Domiciliary Noninvasive Positive-Pressure Ventilation in Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomized Controlled Trials
- Authors
- Park S.Y.; Yoo K.H.; Park Y.B.; Rhee C.K.; Park J.; Park H.Y.; Hwang Y.I.; Park D.A.; Sim Y.S.
- Ewha Authors
- 박소영
- SCOPUS Author ID
- 박소영
- Issue Date
- 2022
- Journal Title
- Tuberculosis and Respiratory Diseases
- ISSN
- 1738-3536
- Citation
- Tuberculosis and Respiratory Diseases vol. 85, no. 1, pp. 47 - 55
- Keywords
- Chronic Obstructive Pulmonary Disease; Mortality; Noninvasive Positive-Pressure Ventilation
- Publisher
- Korean National Tuberculosis Association
- Indexed
- SCOPUS; KCI
- Document Type
- Article
- Abstract
- Background: We evaluated the long-term effects of domiciliary noninvasive positive-pressure ventilation (NIPPV) used to treat patients with chronic obstructive pulmonary disease (COPD). Methods: Databases were searched to identify randomized controlled trials of COPD with NIPPV for longer than 1 year. Mortality rates were the primary outcome in this meta-analysis. The eight trials included in this study comprised data from 913 patients. Results: The mortality rates for the NIPPV and control groups were 29% (118/414) and 36% (151/419), suggesting a statistically significant difference (risk ratio [RR], 0.79; 95% confidence interval [CI], 0.65–0.95). Mortality rates were reduced with NIPPV in four trials that included stable COPD patients. There was no difference in admission, acute exacerbation and quality of life between the NIPPV and control groups. There was no significant difference in withdrawal rates between the two groups (RR, 0.99; 95% CI, 0.72–1.36; p=0.94). Conclusion: Maintaining long-term nocturnal NIPPV for more than 1 year, especially in patients with stable COPD, decreased the mortality rate, without increasing the withdrawal rate compared with long-term oxygen treatment. Copyright © 2022 The Korean Academy of Tuberculosis and Respiratory Diseases.
- DOI
- 10.4046/TRD.2021.0062
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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