Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 문영철 | * |
dc.date.accessioned | 2022-02-22T16:31:25Z | - |
dc.date.available | 2022-02-22T16:31:25Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 2044-5385 | * |
dc.identifier.other | OAK-30700 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260670 | - |
dc.description.abstract | In multiple myeloma (MM), a high number of focal lesions (FL) detected using positron emission tomography/computed tomography (PET/CT) was found to be associated with adverse prognosis. To design a new risk stratification system that combines the Revised International Staging System (R-ISS) with FL, we analyzed the data of 380 patients with newly diagnosed MM (NDMM) who underwent F-18-fluorodeoxyglucose (F-18-FDG) PET/CT upon diagnosis. The K-adaptive partitioning algorithm was adopted to define subgroups with homogeneous survival. The combined R-ISS with PET/CT classified NDMM patients into four groups: R-ISS/PET stage I (n = 31; R-ISS I with FL <= 3), stage II (n = 156; R-ISS I with FL > 3 and R-ISS II with FL <= 3), stage III (n = 162; R-ISS II with FL > 3 and R-ISS III with FL <= 3), and stage IV (n = 31; R-ISS III with FL > 3). The 2-year overall survival rates for stages I, II, III, and IV were 96.7%, 89.8%, 74.7%, and 50.3%. The 2-year progression-free survival rates were 84.1%, 64.7%, 40.8%, and 17.1%, respectively. The new R-ISS/PET was successfully validated in an external cohort. This new system had a remarkable prognostic power for estimating the survival outcomes of patients with NDMM. This system helps discriminate patients with a good prognosis from those with a poor prognosis more precisely. | * |
dc.language | English | * |
dc.publisher | SPRINGERNATURE | * |
dc.title | Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and F-18-FDG PET/CT | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | BLOOD CANCER JOURNAL | * |
dc.identifier.doi | 10.1038/s41408-021-00577-2 | * |
dc.identifier.wosid | WOS:000724755600002 | * |
dc.identifier.scopusid | 2-s2.0-85120408632 | * |
dc.author.google | Cho, Hee Jeong | * |
dc.author.google | Jung, Sung-Hoon | * |
dc.author.google | Jo, Jae-Cheol | * |
dc.author.google | Lee, Yoo Jin | * |
dc.author.google | Yoon, Sang Eun | * |
dc.author.google | Park, Sung-Soo | * |
dc.author.google | Kim, Do Young | * |
dc.author.google | Shin, Ho-Jin | * |
dc.author.google | Mun, Yeung-Chul | * |
dc.author.google | Yi, Jun Ho | * |
dc.author.google | Kim, Hyo Jung | * |
dc.author.google | Kim, Da Jung | * |
dc.author.google | Lee, Ho Sup | * |
dc.author.google | Bae, Sung Hwa | * |
dc.author.google | Hong, Chae Moon | * |
dc.author.google | Jeong, Shin Young | * |
dc.author.google | Min, Jung-Joon | * |
dc.author.google | Sohn, Sang Kyun | * |
dc.author.google | Min, Chang-Ki | * |
dc.author.google | Kim, Kihyun | * |
dc.author.google | Lee, Je-Jung | * |
dc.author.google | Moon, Joon Ho|Korean Multiple Myeloma Workin | * |
dc.contributor.scopusid | 문영철(7003363716) | * |
dc.date.modifydate | 20240422115947 | * |