View : 396 Download: 0
Tunicate-Inspired Photoactivatable Proteinic Nanobombs for Tumor-Adhesive Multimodal Therapy
- Title
- Tunicate-Inspired Photoactivatable Proteinic Nanobombs for Tumor-Adhesive Multimodal Therapy
- Authors
- Jeong, Yeonsu; Jo, Yun Kee; Kim, Mou Seung; Il Joo, Kye; Cha, Hyung Joon
- Ewha Authors
- 주계일
- SCOPUS Author ID
- 주계일
- Issue Date
- 2021
- Journal Title
- ADVANCED HEALTHCARE MATERIALS
- ISSN
- 2192-2640
2192-2659
- Citation
- ADVANCED HEALTHCARE MATERIALS vol. 10, no. 23
- Keywords
- bioinorganic chemistry; multimodal anticancer therapy; NIR-responsive nanotherapeutics; protein-based photothermal agents; vanadium-doping effect
- Publisher
- WILEY
- Indexed
- SCOPUS
- Document Type
- Article
- Abstract
- Near-IR (NIR) light-responsive multimodal nanotherapeutics have been proposed to achieve improved therapeutic efficacy and high specificity in cancer therapy. However, their clinical application is still elusive due to poor biometabolization and short retention at the target site. Here, innovative photoactivatable vanadium-doped adhesive proteinic nanoparticles (NPs) capable of allowing biological photoabsorption and NIR-responsive anticancer therapeutic effects to realize trimodal photothermal-gas-chemo-therapy treatments in a highly biocompatible, site-specific manner are proposed. The photoactivatable tumor-adhesive proteinic NPs can enable efficient photothermal conversion via tunicate-inspired catechol-vanadium complexes as well as prolonged tumor retention by virtue of mussel protein-driven distinctive adhesiveness. The incorporation of a thermo-sensitive nitric oxide donor and doxorubicin into the photoactivatable adhesive proteinic NPs leads to synergistic anticancer therapeutic effects as a result of photothermal-triggered "bomb-like" multimodal actions. Thus, this protein-based phototherapeutic tumor-adhesive NPs have great potential as a spatiotemporally controllable therapeutic system to accomplish effective therapeutic implications for the complete ablation of cancer.
- DOI
- 10.1002/adhm.202101212
- Appears in Collections:
- 공과대학 > 화공신소재공학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML