Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유경하 | * |
dc.contributor.author | 우소연 | * |
dc.contributor.author | 조경아 | * |
dc.contributor.author | 김유희 | * |
dc.date.accessioned | 2022-02-22T16:31:13Z | - |
dc.date.available | 2022-02-22T16:31:13Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1738-2696 | * |
dc.identifier.other | OAK-30693 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260653 | - |
dc.description.abstract | Background:: Mast cells are immune sentinels in the skin that respond to a wide range of pathological and environmental stimuli; they owe their function to the expression of Toll-like receptors (TLRs). We previously found that tonsil-derived mesenchymal stem cells (T-MSCs) were able to effectively attenuate TLR7-mediated skin inflammation in mice, which was accompanied by an increase in mast cell number. The present study investigated whether T-MSC extracellular vesicles, such as exosomes, are able to regulate mast cell activation in response to TLR7 stimulation. Methods:: The HMC-1 human mast cell line was treated with a TLR7 agonist in the presence or absence of T-MSC exosomes, and the levels of expressed inflammatory cytokines were assessed. Additionally, mice were repeatedly injected with a TLR7 agonist with or without interval treatments with T-MSC exosomes and assessed dermal distribution of mast cells and related immune cells. Results:: We showed that T-MSC exosomes containing microRNAs that target inflammatory cytokines significantly reduced the expression of inflammatory cytokines in TLR7 agonist-treated HMC-1 cells. In addition, T-MSC exosomes inhibited the increase in the number of both dermal mast cells and CD14-positive cells in TLR7 agonist-treated mice. Conclusion:: Our data suggest that T-MSC exosomes have regulatory effects on mast cell activation under inflammatory conditions, including TLR7 stimulation. © 2021, The Korean Tissue Engineering and Regenerative Medicine Society. | * |
dc.language | English | * |
dc.publisher | Korean Tissue Engineering and Regenerative Medicine Society | * |
dc.subject | Exosomes | * |
dc.subject | Mast cell | * |
dc.subject | Mesenchymal stem cell | * |
dc.subject | TLR7 | * |
dc.title | Mesenchymal Stem Cell-Derived Exosomes Attenuate TLR7-Mediated Mast Cell Activation | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 117 | * |
dc.relation.lastpage | 129 | * |
dc.relation.journaltitle | Tissue Engineering and Regenerative Medicine | * |
dc.identifier.doi | 10.1007/s13770-021-00395-4 | * |
dc.identifier.wosid | WOS:000720211000001 | * |
dc.identifier.scopusid | 2-s2.0-85119252853 | * |
dc.author.google | Cho K.-A. | * |
dc.author.google | Cha J.-E. | * |
dc.author.google | Kim J. | * |
dc.author.google | Kim Y.-H. | * |
dc.author.google | Ryu K.-H. | * |
dc.author.google | Woo S.-Y. | * |
dc.contributor.scopusid | 유경하(14038236200) | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.contributor.scopusid | 조경아(21734204400) | * |
dc.contributor.scopusid | 김유희(15764983100) | * |
dc.date.modifydate | 20240311140754 | * |