Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이경은 | * |
dc.date.accessioned | 2022-02-22T16:30:05Z | - |
dc.date.available | 2022-02-22T16:30:05Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1226-3303 | * |
dc.identifier.other | OAK-30895 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260549 | - |
dc.description.abstract | Background/Aims: Treatment decisions for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) are complicated, and multi-modal treatments are usually indicated. However, it is challenging for older patients to complete treatments. Thus, we investigated disease characteristics, real-world treatment, and outcomes in older LA-HNSCC patients. Methods: Older patients (aged ≥ 70 years) were selected from a large nationwide cohort that included 445 patients with stage III–IVB LA-HNSCC from January 2005 to December 2015. Their data were retrospectively analyzed and compared with those of younger patients. Results: Older patients accounted for 18.7% (83/445) of all patients with median age was 73 years (range, 70 to 89). Pro-portions of primary tumors in the hypopharynx and larynx were higher in older patients and older patients had a more advanced T stage and worse performance status. Regarding treatment strategies of older patients, 44.5% of patients received concurrent chemoradiotherapy (CCRT), 41.0% underwent surgery, and 14.5% did not complete the planned treatment. Induction chemotherapy (IC) was administered to 27.7% (23/83) of older patients; the preferred regimen for IC was fluoro-uracil and cisplatin (47.9%). For CCRT, weekly cisplatin was prescribed 3.3 times more often than 3-weekly cisplatin (62.2% vs. 18.9%). Older patients had a 60% higher risk of death than younger patients (hazard ratio, 1.6; p = 0.035). Oral cavity cancer patients had the worst survival probability. Conclusions: Older LA-HNSCC patients had aggressive tumor characteristics and received less intensive treatment, resulting in poor survival. Further research focusing on the older population is necessary. © 2022 The Korean Association of Internal Medicine. | * |
dc.language | English | * |
dc.publisher | Korean Association of Internal Medicine | * |
dc.subject | Aged | * |
dc.subject | Head and neck neoplasms | * |
dc.subject | Therapeutics | * |
dc.title | Characteristics and treatment patterns in older patients with locally advanced head and neck cancer (KCSG HN13-01) | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 37 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 190 | * |
dc.relation.lastpage | 200 | * |
dc.relation.journaltitle | Korean Journal of Internal Medicine | * |
dc.identifier.doi | 10.3904/kjim.2020.636 | * |
dc.identifier.wosid | WOS:000737495600001 | * |
dc.identifier.scopusid | 2-s2.0-85123391279 | * |
dc.author.google | Kang E.J. | * |
dc.author.google | Lee Y.-G. | * |
dc.author.google | Keam B. | * |
dc.author.google | Choi J.-H. | * |
dc.author.google | Kim J.-S. | * |
dc.author.google | Park K.U. | * |
dc.author.google | Lee K.E. | * |
dc.author.google | Kim H.J. | * |
dc.author.google | Lee K.-W. | * |
dc.author.google | Kim M.K. | * |
dc.author.google | Ahn H.K. | * |
dc.author.google | Shin S.H. | * |
dc.author.google | Lee J.B. | * |
dc.author.google | Kwon J.H. | * |
dc.author.google | Kim H.R. | * |
dc.author.google | Kim S.-B. | * |
dc.author.google | Yun H.J. | * |
dc.contributor.scopusid | 이경은(7409769243) | * |
dc.date.modifydate | 20231116115921 | * |