Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김규보 | * |
dc.contributor.author | 김경수 | * |
dc.date.accessioned | 2021-12-28T16:30:05Z | - |
dc.date.available | 2021-12-28T16:30:05Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 0960-9776 | * |
dc.identifier.issn | 1532-3080 | * |
dc.identifier.other | OAK-30612 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259689 | - |
dc.description.abstract | Background: To investigate outcomes of salvage whole-brain radiotherapy (WBRT) for recurrent brain metastases (BM) from breast cancer (BC), to identify prognostic factors of overall survival (OS), and to propose a novel prognostic classification for OS in these patients. Materials and methods: We identified 54 patients who had received salvage WBRT as the second brain-focused treatment for recurrent BM from BC (2000-2014). The median follow-up duration was 4.9 months. A recursive partitioning analysis (RPA) was conducted to develop a model to predict OS at the time of salvage WBRT. Results: The median OS was 6.8 months. OS according to BC-specific graded prognostic assessment (breast-GPA), modified breast-GPA, and updated breast-GPA did not represent our cohort. In the multivariate analysis, a long time before salvage WBRT (>= 16 months), control of primary BC or extracranial metastases, systemic treatment after salvage WBRT, and administration of a biologically effective dose for an alpha/beta of 10 Gy (BED10) of salvage WBRT >37.5 Gy showed superior OS. We proposed three RPA classes based on the control of both primary BC and extracranial metastasis and BED10 of salvage WBRT: class I, class II, and class III. In this model, patients with class I experienced the best OS (34.6 months; class II, 5.0 months; class III, 2.4 months; P < 0.001). Conclusions: In our RPA classification according to the control of both primary BC and extracranial metastasis and the dose of salvage WBRT, significant differences in OS were observed. The subsequent use of a systemic treatment showed better OS. (C) 2021 The Authors. Published by Elsevier Ltd. | * |
dc.language | English | * |
dc.publisher | CHURCHILL LIVINGSTONE | * |
dc.subject | Breast cancer | * |
dc.subject | Brain metastasis | * |
dc.subject | Whole-brain radiotherapy | * |
dc.subject | Overall survival | * |
dc.subject | Recursive partitioning analysis | * |
dc.title | Novel prognostic classification predicts overall survival of patients receiving salvage whole-brain radiotherapy for recurrent brain metastasis from breast cancer: A recursive partitioning analysis (KROG 16-12) | * |
dc.type | Article | * |
dc.relation.volume | 60 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 272 | * |
dc.relation.lastpage | 278 | * |
dc.relation.journaltitle | BREAST | * |
dc.identifier.doi | 10.1016/j.breast.2021.11.005 | * |
dc.identifier.wosid | WOS:000744958000036 | * |
dc.identifier.scopusid | 2-s2.0-85119284069 | * |
dc.author.google | Kim, Jae Sik | * |
dc.author.google | Kim, Kyubo | * |
dc.author.google | Jung, Wonguen | * |
dc.author.google | Shin, Kyung Hwan | * |
dc.author.google | Im, Seock-Ah | * |
dc.author.google | Kim, Yong Bae | * |
dc.author.google | Chang, Jee Suk | * |
dc.author.google | Choi, Doo Ho | * |
dc.author.google | Kim, Haeyoung | * |
dc.author.google | Park, Yeon Hee | * |
dc.author.google | Kim, Dae Yong | * |
dc.author.google | Kim, Tae Hyun | * |
dc.author.google | Kwon, Jeanny | * |
dc.author.google | Kang, Ki Mun | * |
dc.author.google | Chung, Woong-Ki | * |
dc.author.google | Kim, Kyung Su | * |
dc.author.google | Kim, In Ah | * |
dc.contributor.scopusid | 김규보(8213302900) | * |
dc.contributor.scopusid | 김경수(57207404412) | * |
dc.date.modifydate | 20240318142630 | * |