Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이경은 | * |
dc.date.accessioned | 2021-11-17T16:31:12Z | - |
dc.date.available | 2021-11-17T16:31:12Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1471-2407 | * |
dc.identifier.other | OAK-27989 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259566 | - |
dc.description.abstract | BackgroundBy investigating treatment patterns and outcomes in locally advanced head and neck squamous cell carcinoma (LA-HNSCC), we aimed at providing valuable insights into the optimal therapeutic strategy for physicians in real-world practice.MethodsThis is a multi-institutional study enrolled the patients with stage III to IVB LA-HNSCC, except for nasopharyngeal carcinoma, from 2004 to 2015 in thirteen referral hospitals capable of multidisciplinary care.ResultsA total of 445 LA-HNSCC patients were analyzed. The median age was 61years (range, 24-89). The primary tumor location was the oropharynx in 191 (43%), oral cavity in 106 (24%), hypopharynx in 64 (14%), larynx in 57 (13%) and other sites in 27 (6%). The most common stage was T2 in 172 (39%), and N2 in 245 (55%). Based on treatment intents, 229 (52%) of the patients received definitive concurrent chemoradiotherapy (CCRT) and 187 (42%) underwent surgery. Approximately 158 (36%) of the study population received induction chemotherapy (IC). Taken together, 385 (87%) of the patients underwent combined therapeutic modalities. The regimen for definitive CCRT was weekly cisplatin in 58%, 3-weekly cisplatin in 28% and cetuximab in 3%. The preferred regimen for IC was docetaxel with cisplatin in 49%, and docetaxel, cisplatin plus fluorouracil in 27%. With a median follow-up of 39months, one-year and two-year survival rates were 89 and 80%, respectively. Overall survival was not significantly different between CCRT and surgery group (p=0.620).ConclusionsIn patients with LA-HNSCC, the majority of patients received combined therapeutic modalities. Definitive CCRT, IC then definitive CCRT, and surgery followed by adjuvant CCRT or radiotherapy are the preferred multidisciplinary strategies in real-world practice. | * |
dc.language | English | * |
dc.publisher | BMC | * |
dc.subject | Locally advanced head and neck cancer | * |
dc.subject | Squamous cell carcinoma | * |
dc.subject | Multidisciplinary treatment | * |
dc.subject | Strategy | * |
dc.title | Treatment strategy and outcomes in locally advanced head and neck squamous cell carcinoma: a nationwide retrospective cohort study (KCSG HN13-01) | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 20 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | BMC CANCER | * |
dc.identifier.doi | 10.1186/s12885-020-07297-z | * |
dc.identifier.wosid | WOS:000567401700001 | * |
dc.identifier.scopusid | 2-s2.0-85090009181 | * |
dc.author.google | Lee, Yun-Gyoo | * |
dc.author.google | Kang, Eun Joo | * |
dc.author.google | Keam, Bhumsuk | * |
dc.author.google | Choi, Jin-Hyuk | * |
dc.author.google | Kim, Jin-Soo | * |
dc.author.google | Park, Keon Uk | * |
dc.author.google | Lee, Kyoung Eun | * |
dc.author.google | Kwon, Jung Hye | * |
dc.author.google | Lee, Keun-Wook | * |
dc.author.google | Kim, Min Kyoung | * |
dc.author.google | Ahn, Hee Kyung | * |
dc.author.google | Shin, Seong Hoon | * |
dc.author.google | Kim, Hye Ryun | * |
dc.author.google | Kim, Sung-Bae | * |
dc.author.google | Yun, Hwan Jung | * |
dc.contributor.scopusid | 이경은(7501517217;58364338700) | * |
dc.date.modifydate | 20240123091958 | * |