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Ambient air pollution and endocrinologic disorders in childhood
- Title
- Ambient air pollution and endocrinologic disorders in childhood
- Authors
- Heo Y.J.; Kim H.S.
- Ewha Authors
- 김혜순; 허유정
- SCOPUS Author ID
- 김혜순; 허유정
- Issue Date
- 2021
- Journal Title
- Annals of Pediatric Endocrinology and Metabolism
- ISSN
- 2287-1012
- Citation
- Annals of Pediatric Endocrinology and Metabolism vol. 26, no. 3, pp. 158 - 170
- Keywords
- Air pollution; Endocrinology; Pediatrics
- Publisher
- Korean society of pediatric endocrinology
- Indexed
- SCOPUS
- Document Type
- Review
- Abstract
- Ambient air pollution has been proposed as an important environmental risk factor that increases global mortality and morbidity. Over the past decade, several human and animal studies have reported an association between exposure to air pollution and altered metabolic and endocrine systems in children. However, the results for these studies were mixed and inconclusive and did not demonstrate causality because different outcomes were observed due to different study designs, exposure periods, and methodologies for exposure measurements. Current proposed mechanisms include altered immune response, oxidative stress, neuroinflammation, inadequate placental development, and epigenetic modulation. In this review, we summarized the results of previous pediatric studies that reported effects of prenatal and postnatal air pollution exposure on childhood type 1 diabetes mellitus, obesity, insulin resistance, thyroid dysfunction, and timing of pubertal onset, along with underlying related mechanisms. © 2021 Annals of Pediatric Endocrinology & Metabolism.
- DOI
- 10.6065/apem.2142132.066
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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