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Better oral hygiene is associated with lower risk of stroke
- Title
- Better oral hygiene is associated with lower risk of stroke
- Authors
- Chang, Yoonkyung; Woo, Ho Geol; Lee, Ji Sung; Song, Tae-Jin
- Ewha Authors
- 송태진; 장윤경; 우호걸
- SCOPUS Author ID
- 송태진; 장윤경; 우호걸
- Issue Date
- 2021
- Journal Title
- JOURNAL OF PERIODONTOLOGY
- ISSN
- 0022-3492
1943-3670
- Citation
- JOURNAL OF PERIODONTOLOGY vol. 92, no. 1, pp. 87 - 94
- Keywords
- cerebral hemorrhage; cerebral infarction; oral hygiene; stroke; subarachnoid hemorrhage; toothbrushing
- Publisher
- WILEY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background Periodontal disease or poor oral hygiene may lead to local infection, inflammation, and systemic inflammatory reactions, which are important mediators of development of stroke. We aimed to investigate the association of oral hygiene with risk of stroke in a nationwide population-based cohort. Methods From Korean National Health Insurance System-Health Screening Cohort, 206,602 participants without missing data regarding demographic information, medical history, or blood/urine examination results were included. The presence of periodontal disease and indicators of oral hygiene, such as number of tooth brushings, dental visit history, dental scaling, and number of teeth loss and dental caries were evaluated. Occurrence of stroke including cerebral infarction, cerebral hemorrhage, and subarachnoid hemorrhage was defined as newly registration of International Classification of Diseases-10 codes from I60 to I64 accompanying brain CT and/or MR examination at that time of diagnosis. Results The 7337 (3.6%) cases of stroke including 5795 (79.0%) cases of cerebral infarction, 1568 (21.4%) cases of cerebral hemorrhage, and 621 (8.5%) cases of subarachnoid hemorrhage occurred during a median 10.4 years follow-up. In multivariable analysis, frequent tooth brushing (>= 3 times per day) was negatively associated with risk of stroke occurrence (hazard ratio [HR]: 0.78, 95% confidence interval [CI]: 0.73-0.84). Number of dental caries (>= 4) was positively related to stroke occurrence (HR: 1.28, 95% CI: 1.13-1.44). Conclusions Regular oral hygiene behavior was negatively, and infrequent oral hygiene care was positively associated with risk of occurrence for stroke, respectively. Brushing one's teeth three or more times daily may be associated with lower risk of stroke.
- DOI
- 10.1002/JPER.20-0053
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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