Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강은정 | * |
dc.date.accessioned | 2021-11-10T16:31:10Z | - |
dc.date.available | 2021-11-10T16:31:10Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 2296-858X | * |
dc.identifier.other | OAK-30071 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259349 | - |
dc.description.abstract | Background: We aimed to evaluate serum bicarbonate as a risk factor for renal progression, cardiovascular events, and mortality in Korean CKD patients. Methods: We analyzed 1,808 participants from a Korean CKD cohort whose serum bicarbonate levels were measured at enrollment. Serum bicarbonate levels were categorized as low, lower normal, higher normal, and high (total carbon dioxide <22, 22-26, 26.1-29.9, and >= 30 mmol/L, respectively) groups. Metabolic acidosis was defined as a serum bicarbonate level <22 mmol/L. The primary outcome was renal events defined as doubling of serum creatinine, 50% reduction of eGFR from the baseline values, or development of end-stage kidney disease. The secondary outcome consisted of cardiovascular events and death. In addition, patients whose eGFR values were measured more than three times during the follow-up period were analyzed for eGFR decline. The rapid decline in eGFR was defined as lower than the median value of the eGFR slope. Results: The mean serum bicarbonate level was 25.7 +/- 3.7 mmol/L and 240 (13.2%) patients had metabolic acidosis. During the follow-up period of 55.2 +/- 24.1 months, 545 (30.9%) patients developed renal events and 187 (10.6%) patients developed a composite of cardiovascular events and death. After adjustment, the low serum bicarbonate group experienced 1.27 times more renal events than the lower normal bicarbonate group [hazard ratio (HR): 1.27; 95% CI: 1.01-1.60, P = 0.043]. There was no significant association between the bicarbonate groups and the composite outcome of cardiovascular events and death. The low bicarbonate group showed a significantly rapid decline in eGFR [odds ratio (OR): 2.12; 95% CI: 1.39-3.22, P < 0.001] compared to the lower normal bicarbonate group. Conclusions: Metabolic acidosis was significantly associated with increased renal events and a rapid decline in renal function in Korean predialysis CKD patients. | * |
dc.language | English | * |
dc.publisher | FRONTIERS MEDIA SA | * |
dc.subject | metabolic acidosis | * |
dc.subject | serum bicarbonate | * |
dc.subject | chronic kidney disease | * |
dc.subject | renal progression | * |
dc.subject | renal function decline | * |
dc.title | Metabolic Acidosis Is an Independent Risk Factor of Renal Progression in Korean Chronic Kidney Disease Patients: The KNOW-CKD Study Results | * |
dc.type | Article | * |
dc.relation.volume | 8 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | FRONTIERS IN MEDICINE | * |
dc.identifier.doi | 10.3389/fmed.2021.707588 | * |
dc.identifier.wosid | WOS:000684669900001 | * |
dc.author.google | Kim, Hyo Jin | * |
dc.author.google | Ryu, Hyunjin | * |
dc.author.google | Kang, Eunjeong | * |
dc.author.google | Kang, Minjung | * |
dc.author.google | Han, Miyeun | * |
dc.author.google | Song, Sang Heon | * |
dc.author.google | Lee, Joongyub | * |
dc.author.google | Jung, Ji Yong | * |
dc.author.google | Lee, Kyu-Beck | * |
dc.author.google | Sung, Suah | * |
dc.author.google | Seong, Eun Young | * |
dc.author.google | Ahn, Curie | * |
dc.author.google | Oh, Kook-Hwan | * |
dc.contributor.scopusid | 강은정(56577278700) | * |
dc.date.modifydate | 20240315133203 | * |