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Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study
- Title
- Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study
- Authors
- Kang, Sarang; Gim, Jungsoo; Lee, Jiwoon; Gunasekaran, Tamil Iniyan; Choi, Kyu Yeong; Lee, Jang Jae; Seo, Eun Hyun; Ko, Pan-Woo; Chung, Ji Yeon; Choi, Seong-Min; Lee, Young Min; Jeong, Jee Hyang; Park, Kyung Won; Song, Min Kyung; Lee, Ho-Won; Kim, Ki Woong; Choi, Seong Hye; Lee, Dong Young; Kim, Sang Yun; Kim, Hoowon; Kim, Byeong C.; Ikeuchi, Takeshi; Lee, Kun Ho
- Ewha Authors
- 정지향
- SCOPUS Author ID
- 정지향
- Issue Date
- 2021
- Journal Title
- JOURNAL OF ALZHEIMERS DISEASE
- ISSN
- 1387-2877
1875-8908
- Citation
- JOURNAL OF ALZHEIMERS DISEASE vol. 82, no. 4, pp. 1451 - 1460
- Keywords
- Alzheimer's disease; APOE; genome-wide association study; late-onset Alzheimer's disease; stratified genome analysis
- Publisher
- IOS PRESS
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The present study reports two novel genome-wide significant loci for late-onset Alzheimer's disease (LOAD) identified from APOE epsilon 4 non-carrier subjects of East Asian origin. A genome-wide association study of Alzheimer's disease was performed in 2,291 Korean seniors in the discovery phase, from the Gwangju Alzheimer's and Related Dementias (GARD) cohort study. The study was replicated in a Japanese cohort of 1,956 subjects that suggested two novel susceptible SNPs in two genes: PRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants is feasible in non-European ethnic groups using samples comprising fewer subjects from the more homogeneous genetic background.
- DOI
- 10.3233/JAD-210145
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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