Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유경하 | * |
dc.contributor.author | 우소연 | * |
dc.contributor.author | 조경아 | * |
dc.contributor.author | 김유희 | * |
dc.date.accessioned | 2021-11-10T16:31:07Z | - |
dc.date.available | 2021-11-10T16:31:07Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 2073-4409 | * |
dc.identifier.other | OAK-30105 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259330 | - |
dc.description.abstract | Skeletal muscle mass is decreased under a wide range of pathologic conditions. In particular, chemotherapy is well known for inducing muscle loss and atrophy. Previous studies using tonsil-derived mesenchymal stem cells (T-MSCs) or a T-MSC-conditioned medium showed effective recovery of total body weight in the chemotherapy-preconditioned bone marrow transplantation mouse model. This study investigated whether extracellular vesicles of T-MSCs, such as exosomes, are a key player in the recovery of body weight and skeletal muscle mass in chemotherapy-treated mice. T-MSC exosomes transplantation significantly decreased loss of total body weight and muscle mass in the busulfan-cyclophosphamide conditioning regimen in BALB/c recipient mice containing elevated serum activin A. Additionally, T-MSC exosomes rescued impaired C2C12 cell differentiation in the presence of activin A in vitro. We found that T-MSC exosomes possess abundant miR-145-5p, which targets activin A receptors, ACVR2A, and ACVR1B. Indeed, T-MSC exosomes rescue muscle atrophy both in vivo and in vitro via miR-145-5p dependent manner. These results suggest that T-MSC exosomes have therapeutic potential to maintain or improve skeletal muscle mass in various activin A elevated pathologic conditions. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | mesenchymal stem cell | * |
dc.subject | exosomes | * |
dc.subject | skeletal muscle | * |
dc.subject | activin A | * |
dc.title | Mesenchymal Stem Cell-Derived Exosomes Protect Muscle Loss by miR-145-5p Activity Targeting Activin A Receptors | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 10 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | CELLS | * |
dc.identifier.doi | 10.3390/cells10082169 | * |
dc.identifier.wosid | WOS:000688955100001 | * |
dc.author.google | Cho, Kyung-Ah | * |
dc.author.google | Choi, Da-Won | * |
dc.author.google | Kim, Yu-Hee | * |
dc.author.google | Kim, Jungwoo | * |
dc.author.google | Ryu, Kyung-Ha | * |
dc.author.google | Woo, So-Youn | * |
dc.contributor.scopusid | 유경하(14038236200) | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.contributor.scopusid | 조경아(21734204400) | * |
dc.contributor.scopusid | 김유희(15764983100) | * |
dc.date.modifydate | 20240311140754 | * |