Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박혜경 | * |
dc.contributor.author | 정지향 | * |
dc.contributor.author | 김범산 | * |
dc.contributor.author | 김건하 | * |
dc.contributor.author | 윤혜전 | * |
dc.date.accessioned | 2021-11-10T16:31:06Z | - |
dc.date.available | 2021-11-10T16:31:06Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 2213-1582 | * |
dc.identifier.other | OAK-30112 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259325 | - |
dc.description.abstract | Background: This study investigated changes in brain perfusion and A beta burden according to the progression of Alzheimer's disease (AD) by using a dual-phase 18F-florbetaben (FBB) PET protocol. Methods: Sixty subjects, including 12 with A beta-negative normal cognition (A beta-NC), 32 with A beta-positive mild cognitive impairment (A beta+MCI), and 16 with A beta-positive AD (A beta+AD), were enrolled. A dynamic PET scan was obtained in the early phase (0-10 min, eFBB) and delayed phase (90-110 min, dFBB), which were then averaged into a single frame, respectively. In addition to the averaged eFBB, an R1 parametric map was calculated from the eFBB scan based on a simplified reference tissue model (SRTM). Between-group regional and voxel-wise analyses of the images were performed. The associations between cognitive profiles and PET-derived parameters were investigated. Results: Both the R1 and eFBB perfusion reductions in the cortical regions were not significantly different between the A beta-NC and A beta+MCI groups, while they were significantly reduced from the A beta+MCI to A beta+AD groups in regional and voxel-wise analyses. However, cortical A beta depositions on dFBB were not significantly different between the A beta+MCI and A beta+AD groups. There were strong positive correlations between the R1 and eFBB images in regional and voxel-wise analyses. Both perfusion components showed significant correlations with general and specific cognitive profiles. Conclusion: The results of this study demonstrated the feasibility of dual-phase 18F-FBB PET to evaluate different trajectories of dual biomarkers for neurodegeneration and A beta burden over the course of AD. In addition, both eFBB and SRTM-based R1 can provide robust indices of brain perfusion. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCI LTD | * |
dc.subject | F-18-florbetaben | * |
dc.subject | Positron emission tomography | * |
dc.subject | Dual-phase | * |
dc.subject | R1 | * |
dc.subject | Alzheimer's disease | * |
dc.title | Dual-phase F-18-florbetaben PET provides cerebral perfusion proxy along with beta-amyloid burden in Alzheimer's disease | * |
dc.type | Article | * |
dc.relation.volume | 31 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | NEUROIMAGE-CLINICAL | * |
dc.identifier.doi | 10.1016/j.nicl.2021.102773 | * |
dc.identifier.wosid | WOS:000689670300001 | * |
dc.identifier.scopusid | 2-s2.0-85111490496 | * |
dc.author.google | Yoon, Hai-Jeon | * |
dc.author.google | Kim, Bom Sahn | * |
dc.author.google | Jeong, Jee Hyang | * |
dc.author.google | Kim, Geon Ha | * |
dc.author.google | Park, Hee Kyung | * |
dc.author.google | Chun, Min Young | * |
dc.author.google | Ha, Seunggyun | * |
dc.contributor.scopusid | 박혜경(36014150800) | * |
dc.contributor.scopusid | 정지향(7402045750;57192068764) | * |
dc.contributor.scopusid | 김범산(35223582600) | * |
dc.contributor.scopusid | 김건하(36554502600) | * |
dc.contributor.scopusid | 윤혜전(47161772300) | * |
dc.date.modifydate | 20240423081003 | * |