Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이동현 | - |
dc.date.accessioned | 2021-11-10T16:31:02Z | - |
dc.date.available | 2021-11-10T16:31:02Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2234-943X | - |
dc.identifier.other | OAK-30154 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259300 | - |
dc.description.abstract | Purpose The aim of this study is to investigate the prognostic role of programmed death ligand-1 (PD-L1) on tumor-infiltrating immune cells (TIICs) in patients after radical cystectomy (RC) for bladder cancer (BCa). Materials and Methods We retrospectively reviewed 92 "high-risk" (>= pT3a and/or pN+) patients who underwent RC for BCa, without adjuvant chemotherapy (AC), between April 2014 and December 2019. PD-L1 on TIICs was measured only using the VENTANA (SP-142) immunohistochemistry assay. Patients were categorized into three groups based to the percentage of the tumor area covered by PD-L1 on TIICs: IC0 (<1%), IC1 (>= 1% and <5%), and IC2/3 (>= 5%). Positive PD-L1 was defined as IC2/3 (>= 5%). Kaplan-Meier survival analysis was used to illustrate recurrence-free survival (RFS), and Cox proportional hazard models were used to identify predictive factors of tumor recurrence. Results Within the cohort, the proportions of PD-L1 IC0, IC1, and IC2/3 were 21.7%, 23.9%, and 54.4%, respectively. At follow-up (mean 31.3 months), tumor recurrence was identified in 49 patients (53.3%). Using multivariable analysis, tumor stage (pT4; P=0.005), positive lymph nodes (P=0.021), and positive PD-L1 on TIICs (P=0.010) were independent predictors of tumor recurrence. The 2- and 3-year RFS rates were 67.7% and 64.2% in negative PD-L1 on TIICs, while 27.8% and 22.3% in positive PD-L1 on TIICs, respectively. Conclusions Positive PD-L1 on TIICs was significantly associated with poorer RFS in "high-risk" patients after RC without AC. Our results support the use of adjuvant immunotherapy in "high-risk" patients with positive PD-L1 on TIICs after RC. | - |
dc.language | English | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.subject | high-risk | - |
dc.subject | programmed death ligand-1 | - |
dc.subject | radical cystectomy | - |
dc.subject | recurrence | - |
dc.subject | tumor-infiltrating immune cell | - |
dc.title | Prognostic Role of Programmed Death Ligand-1 on Tumor-Infiltrating Immune Cells in "High-Risk" Patients Following Radical Cystectomy: A Retrospective Cohort Study | - |
dc.type | Article | - |
dc.relation.volume | 11 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | FRONTIERS IN ONCOLOGY | - |
dc.identifier.doi | 10.3389/fonc.2021.706503 | - |
dc.identifier.wosid | WOS:000693649900001 | - |
dc.author.google | Lee, Chung Un | - |
dc.author.google | Lee, Dong Hyeon | - |
dc.author.google | Song, Wan | - |
dc.contributor.scopusid | 이동현(24341048900;57202299352) | - |
dc.date.modifydate | 20230331134421 | - |