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Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014-2019
- Title
- Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014-2019
- Authors
- Yun, Ki Wook; Rhie, Kyuyol; Kang, Jin Han; Kim, Kyung-Hyo; Ahn, Jong Gyun; Kim, Yae-Jean; Eun, Byung Wook; Oh, Sung Hee; Cho, Hye-Kyung; Hong, Young Jin; Kim, Nam Hee; Kim, Yun-Kyung; Lee, Hyunju; Lee, Taekjin; Kim, Hwang Min; Cho, Eun Young; Kim, Chun Soo; Park, Su Eun; Oh, Chi Eun; Jo, Dae Sun; Song, Eun Song; Lee, Jina; Choi, Jae Hong; Lee, Joon Kee; Lee, Hoan Jong; Choi, Eun Hwa
- Ewha Authors
- 김경효
- SCOPUS Author ID
- 김경효
- Issue Date
- 2021
- Journal Title
- VACCINE
- ISSN
- 0264-410X
1873-2518
- Citation
- VACCINE vol. 39, no. 40, pp. 5787 - 5793
- Keywords
- Streptococcus pneumoniae; Serotype; Genotype; Children
- Publisher
- ELSEVIER SCI LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Replacement with nonvaccine serotypes (NVTs) among invasive pneumococcal diseases (IPDs) after the introduction of extended-valency pneumococcal conjugate vaccines varies in predominant serotypes across countries. This study analyzed changes in serotype distribution through serotyping, multilocus sequence typing, and antimicrobial susceptibility testing of 168 pediatric IPD isolates obtained from a multihospital-based surveillance system during 2014-2019 in South Korea. Vaccine serotypes (VTs) accounted for 16.1% (19A, 10.1%; 6A, 1.8%; and 19F 1.8%), 82.1% were NVTs (10A, 23.8%; 15A, 8.3%; 12F, 6.5%; 15C, 6.5%; and 15B, 6.0%), and three (1.8%) were nontypeable. Serotype 10A was the most com-mon serotype, with a significant increase from 11.5% in 2014 to 33.3% in 2019 (p < 0.05 for the trend). Other NVTs decreased from 70.4% to 41.7% between 2015 and 2019, most notably in serotype 12F (from 14.8% to 0%). Almost all (95.0%) serotype 10A isolates were ST11189, which were multidrug resistant. (c) 2021 Elsevier Ltd. All rights reserved.
- DOI
- 10.1016/j.vaccine.2021.08.072
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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