Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정성애 | * |
dc.contributor.author | 정혜경 | * |
dc.contributor.author | 심기남 | * |
dc.contributor.author | 김성은 | * |
dc.contributor.author | 조인호 | * |
dc.contributor.author | 문창모 | * |
dc.contributor.author | 조경아 | * |
dc.contributor.author | 태정현 | * |
dc.contributor.author | 송은미 | * |
dc.contributor.author | 박예현 | * |
dc.contributor.author | 최아름 | * |
dc.contributor.author | 홍지택 | * |
dc.date.accessioned | 2021-11-09T16:31:07Z | - |
dc.date.available | 2021-11-09T16:31:07Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-30230 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259248 | - |
dc.description.abstract | Tonsil-derived mesenchymal stem cells (TMSCs) showed therapeutic effects on acute and chronic murine colitis models, owing to their immunomodulatory properties; therefore, we evaluated enhanced therapeutic effects of TMSCs on a murine colitis model using three-dimensional (3D) culture method. The expression of angiogenic factors, VEGF, and anti-inflammatory cytokines, IL-10, TSG-6, TGF-β, and IDO-1, was significantly higher in the 3D-TMSC-treated group than in the 2D-TMSC-treated group (P < 0.05). At days 18 and 30 after inducing chronic colitis, disease activity index scores were estimated to be significantly lower in the 3D-TMSC-treated group than in the colitis control (P < 0.001 and P < 0.001, respectively) and 2D-TMSC-treated groups (P = 0.022 and P = 0.004, respectively). Body weight loss was significantly lower in the 3D-TMSC-treated group than in the colitis control (P < 0.001) and 2D-TMSC-treated groups (P = 0.005). Colon length shortening was significantly recovered in the 3D-TMSC-treated group compared to that in the 2D-TMSC-treated group (P = 0.001). Histological scoring index was significantly lower in the 3D-TMSC-treated group than in the 2D-TMSC-treated group (P = 0.002). These results indicate that 3D-cultured TMSCs showed considerably higher therapeutic effects in a chronic murine colitis model than those of 2D-cultured TMSCs via increased anti-inflammatory cytokine expression. © 2021, The Author(s). | * |
dc.language | English | * |
dc.publisher | Nature Research | * |
dc.title | Three-dimensional culture method enhances the therapeutic efficacies of tonsil-derived mesenchymal stem cells in murine chronic colitis model | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Scientific Reports | * |
dc.identifier.doi | 10.1038/s41598-021-98711-4 | * |
dc.identifier.wosid | WOS:000702752900010 | * |
dc.identifier.scopusid | 2-s2.0-85116330554 | * |
dc.author.google | Song E.M. | * |
dc.author.google | Joo Y.H. | * |
dc.author.google | Choe A.R. | * |
dc.author.google | Park Y. | * |
dc.author.google | Tae C.H. | * |
dc.author.google | Hong J.T. | * |
dc.author.google | Moon C.M. | * |
dc.author.google | Kim S.-E. | * |
dc.author.google | Jung H.-K. | * |
dc.author.google | Shim K.-N. | * |
dc.author.google | Cho K.-A. | * |
dc.author.google | Jo I. | * |
dc.author.google | Jung S.-A. | * |
dc.contributor.scopusid | 정성애(7403676915) | * |
dc.contributor.scopusid | 정혜경(7403029723) | * |
dc.contributor.scopusid | 심기남(13604838300) | * |
dc.contributor.scopusid | 김성은(35210756100;57204243828) | * |
dc.contributor.scopusid | 조인호(26643129000;56663841900) | * |
dc.contributor.scopusid | 문창모(8131765500) | * |
dc.contributor.scopusid | 조경아(21734204400) | * |
dc.contributor.scopusid | 태정현(35211966400) | * |
dc.contributor.scopusid | 송은미(57193312165) | * |
dc.contributor.scopusid | 박예현(57189612550) | * |
dc.contributor.scopusid | 최아름(57190020909) | * |
dc.contributor.scopusid | 홍지택(57284959800;57206887950) | * |
dc.date.modifydate | 20240422125929 | * |