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The influence of neuromuscular blockade on phase lag entropy and bispectral index: A randomized, controlled trial
- Title
- The influence of neuromuscular blockade on phase lag entropy and bispectral index: A randomized, controlled trial
- Authors
- Jin, Sohee; Baik, Hee Jung; Cho, Sooyoung; Chung, Rack Kyung; Kong, Kyoung Ae; Kim, Youn Jin
- Ewha Authors
- 정락경; 백희정; 김윤진; 공경애; 조수영
- SCOPUS Author ID
- 정락경; 백희정; 김윤진; 공경애; 조수영
- Issue Date
- 2021
- Journal Title
- PLOS ONE
- ISSN
- 1932-6203
- Citation
- PLOS ONE vol. 16, no. 9
- Publisher
- PUBLIC LIBRARY SCIENCE
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The aim of this study is to compare the effects of neuromuscular blockade (NMB) on phase lag entropy (PLE) and the bispectral index (BIS). We recorded the BIS, electromyograph (EMG) activity on a BIS monitor (EMG_BIS), PLE, and EMG activity on a PLE monitor (EMG_PLE) in 40 patients receiving general anesthesia. During the awake state, we analyzed the changes in parameters before and 2 min after the eyes were closed. During sedation, we compared the changes in the parameters before and at 4 min after injecting rocuronium (group R) or normal saline (group C) between the two groups. During anesthesia, we compared the changes in parameters before and at 4 min after injecting sugammadex (group B) or normal saline (group D) between the two groups. During the awake state, the BIS, EMG_BIS, and EMG_PLE, but not PLE, decreased significantly with closed eyes. An effect of EMG on the BIS was evident, but not on PLE. During sedation, the BIS decreased with the decrease in EMG_BIS regardless of NMB caused by rocuronium, but NMB decreased PLE, although the degree of the decrease in EMG_PLE after NMB was similar to that after placebo. To determine the effect of NMB on electroencephalograms (EEGs) in groups R and C, we plotted the power spectra before and at 4 min after injecting rocuronium or normal saline. Changes in slow and delta frequency bands were observed at 4 min after injecting rocuronium relative to before injecting rocuronium. There was no effect of EMG on either the BIS or PLE during anesthesia. In conclusion, the effect of electromyograph activity and/or neuromuscular blockade on BIS or PLE depends on the level of consciousness.
- DOI
- 10.1371/journal.pone.0257467
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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journal.pone.0257467.pdf(1.23 MB)
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