Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유은희 | * |
dc.contributor.author | 문병인 | * |
dc.contributor.author | 임우성 | * |
dc.contributor.author | 권형주 | * |
dc.contributor.author | 우주현 | * |
dc.date.accessioned | 2021-11-09T16:30:57Z | - |
dc.date.available | 2021-11-09T16:30:57Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1932-6203 | * |
dc.identifier.other | OAK-30299 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259183 | - |
dc.description.abstract | The response rate to treatment with trastuzumab (Tz), a recombinant humanized anti-HER2 monoclonal antibody, is only 12-34% despite demonstrated effectiveness on improving the survival of patients with HER2-positive breast cancers. Selenium has an antitumor effect against cancer cells and can play a cytoprotective role on normal cells. This study investigated the effect of selenium on HER2-positive breast cancer cells and the mechanism in relation to the response of the cells to Tz. HER2-positive breast cancer cell lines, SK-BR-3 as trastuzumab-sensitive cells, and JIMT-1 as Tz-resistant cells were treated with Tz and sodium selenite (selenite). Cell survival rates and expression of Her2, Akt, and autophagy-related proteins, including LC3B and beclin 1, in both cell lines 72 h after treatment were evaluated. Significant cell death was induced at different concentrations of selenite in both cell lines. A combined effect of selenite and Tz at 72 h was similar to or significantly greater than each drug alone. The expression of phosphorylated Akt (p-Akt) was decreased in JIMT-1 after combination treatment compared to that after only Tz treatment, while p-Akt expression was increased in SK-BR-3. The expression of beclin1 increased particularly in JIMT-1 after only Tz treatment and was downregulated by combination treatment. These results showed that combination of Tz and selenite had an antitumor effect in Tz-resistant breast cancer cells through downregulation of phosphorylated Akt and beclin1-related autophagy. Selenite might be a potent drug to treat Tz-resistant breast cancer by several mechanisms. | * |
dc.language | English | * |
dc.publisher | PUBLIC LIBRARY SCIENCE | * |
dc.title | Selenium inhibits growth of trastuzumab-resistant human breast cancer cells via downregulation of Akt and beclin-1 | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 16 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | PLOS ONE | * |
dc.identifier.doi | 10.1371/journal.pone.0257298 | * |
dc.identifier.wosid | WOS:000707084400030 | * |
dc.identifier.scopusid | 2-s2.0-85115003942 | * |
dc.author.google | Woo, Joohyun | * |
dc.author.google | Kim, Jong Bin | * |
dc.author.google | Cho, Taeeun | * |
dc.author.google | Yoo, Eun Hye | * |
dc.author.google | Moon, Byung-In | * |
dc.author.google | Kwon, Hyungju | * |
dc.author.google | Lim, Woosung | * |
dc.contributor.scopusid | 유은희(57260790000) | * |
dc.contributor.scopusid | 문병인(7101878644;56119062300) | * |
dc.contributor.scopusid | 임우성(27167744500) | * |
dc.contributor.scopusid | 권형주(57189926616) | * |
dc.contributor.scopusid | 우주현(56211277800) | * |
dc.date.modifydate | 20240318132538 | * |