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Predictors of general discomfort, limitations in activities of daily living and intention of a second donation in unrelated hematopoietic stem cell donation
- Title
- Predictors of general discomfort, limitations in activities of daily living and intention of a second donation in unrelated hematopoietic stem cell donation
- Authors
- Lee, M. H.; Jang, J. H.; Min, H. J.; Jang, H. I.; Nah, J. H.; Lyu, C. J.; Han, K-S; Won, J. H.; Lee, Y-H; Chong, S. Y.; Mun, Y. C.; Lee, W. S.; Kim, S. J.; Kim, I.
- Ewha Authors
- 문영철
- SCOPUS Author ID
- 문영철
- Issue Date
- 2017
- Journal Title
- BONE MARROW TRANSPLANTATION
- ISSN
- 0268-3369
1476-5365
- Citation
- BONE MARROW TRANSPLANTATION vol. 52, no. 2, pp. 258 - 263
- Publisher
- NATURE PUBLISHING GROUP
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- We performed a retrospective study of 1868 consecutive unrelated donors to predict the risk factors related to general discomfort, limitations in activities of daily living (ADLs) and intention of a second donation in hematopoietic stem cell (HSC) donation. General discomfort and limitations in ADLs were assessed by numerical measurement (scores of 0-10) and donor's intention of a second donation by yes or no reply. The post-donation questionnaires were completed within 48 h after HSC collection and at 1 week, 4 weeks, and 4 months thereafter. Predictors of general discomfort included female sex (P < 0.0001), bone marrow (BM) collection (Po0.0001) or PBSC collection through a central line (CL; P = 0.0349), 2-day collection (P = 0.0150) and negative or undetermined intention of a second donation on day 1 (P < 0.0001). Predictors of limitations in ADLs included age group of 30-39 years (P = 0.0046), female sex (P< 0.0001), BM collection (P < 0.0001) or PBSC collection through a CL (Po0.0001) and negative or undetermined intention of a second donation on day 1 (P < 0.0001). The only predictor of positive intention of a second donation was male sex (P = 0.0007). Age, sex and collection method and period should be considered risk factors when unrelated HSC donation is performed.
- DOI
- 10.1038/bmt.2016.260
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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