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Asymmetric Amyloid Deposition as an Early Sign of Progression in Mild Cognitive Impairment Due to Alzheimer Disease
- Title
- Asymmetric Amyloid Deposition as an Early Sign of Progression in Mild Cognitive Impairment Due to Alzheimer Disease
- Authors
- Yoon H.-J.; Kim B.S.; Jeong J.H.; Kim G.H.; Park H.K.; Chun M.Y.
- Ewha Authors
- 정지향; 김범산; 김건하; 윤혜전
- SCOPUS Author ID
- 정지향; 김범산; 김건하; 윤혜전
- Issue Date
- 2021
- Journal Title
- Clinical Nuclear Medicine
- ISSN
- 0363-9762
- Citation
- Clinical Nuclear Medicine vol. 46, no. 7, pp. 527 - 531
- Keywords
- 18F-florbetaben (FBB); Alzheimer disease with dementia; amyloid deposition; asymmetry index; mild cognitive impairment; PET
- Publisher
- Lippincott Williams and Wilkins
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Purpose In typical Alzheimer disease with dementia (ADD), amyloid pathologies affect both cerebral hemispheres symmetrically. However, the spatial distribution of amyloid-ß (Aß) in the early stage of ADD or over the course of disease has not been investigated. Therefore, we explored asymmetric pattern of Aß deposition in both hemispheres according to the ADD continuum using 18F-florbetaben PET. Methods Sixty-eight subjects, including 15 Aß-negative normal controls, 28 Aß-positive mild cognitive impairment (Aß+ MCI), and 25 Aß-positive ADD (Aß+ ADD) subjects, were enrolled. Differences in the asymmetry index and SUV ratio in each of the 6 target regions (4 cortical lobes, cingulate, precuneus) plus composite region between groups were explored. Results The composite and target regional asymmetry indices were significantly different between groups and was highest in Aß+ MCI (composite, occipital, and temporal, P < 0.001; frontal, P = 0.004). The composite and target regional SUV ratios were significantly different according to 3 groups with gradual increase and were highest in Aß+ ADD (composite and all target regions, P < 0.001). Conclusions The asymmetric pattern of amyloid deposition was distinct between Aß-negative normal controls and Aß+ MCI. This pattern disappeared as the disease progressed. These data indicate that asymmetric amyloid deposition may be an early sign of MCI over the course of ADD. © Wolters Kluwer Health, Inc. All rights reserved.
- DOI
- 10.1097/RLU.0000000000003662
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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