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The cancer risk according to three subtypes of ANCA-associated vasculitis: A propensity score-matched analysis of a nationwide study
- Title
- The cancer risk according to three subtypes of ANCA-associated vasculitis: A propensity score-matched analysis of a nationwide study
- Authors
- Choi, Sang Tae; Ahn, Song Vogue; Lee, Poong Hoon; Moon, Chang Mo
- Ewha Authors
- 문창모; 안성복
- SCOPUS Author ID
- 문창모; 안성복
- Issue Date
- 2021
- Journal Title
- SEMINARS IN ARTHRITIS AND RHEUMATISM
- ISSN
- 0049-0172
1532-866X
- Citation
- SEMINARS IN ARTHRITIS AND RHEUMATISM vol. 51, no. 4, pp. 692 - 699
- Keywords
- Antineutrophilic cytoplasmic antibody; Vasculitis; Cancer; Cyclophosphamide; Rituximab
- Publisher
- W B SAUNDERS CO-ELSEVIER INC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Objective: It remains unknown whether cancer risk differs among the three subtypes of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and what the cancer risk factors are. We conducted a nationwide study in Korea to evaluate the risk of cancer in patients with AAV and to identify the risk factors for cancer. Methods: We analyzed the Health Insurance Review and Assessment database of Korea and identified 1982 patients diagnosed with AAV between January 1, 2007 and December 31, 2017. The patients and controls with no history of AAV or cancer were matched 1:4 by propensity scores. The study outcome measure was incidence of cancer during 11 years of follow-up. Results: Patients with granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA) numbered 684, 606, and 692, respectively. The overall incidence of cancer was higher among patients with AAV than in controls (HR 1.32, 95% CI 1.08-1.61). The risk of hematological malignancy, lung cancer, and bladder cancer in the GPA group, lung cancer in the MPA group, and hematological malignancy in the EGPA group were significantly higher than in controls (HR 7.39, 3.20, 4.20, 2.86, and 4.65, respectively). Age, male sex, GPA subtype, and cyclophosphamide use were signifi-cantly associated with cancer risk in patients with AAV. Conclusion: Overall cancer incidence was increased in patients with AAV. Cancer risk was higher in patients with GPA than in those with MPA or EGPA. The use of cyclophosphamide was associated with an increased risk of cancer, while rituximab was not. (c) 2021 Published by Elsevier Inc.
- DOI
- 10.1016/j.semarthrit.2021.03.014
- Appears in Collections:
- 신산업융합대학 > 융합보건학과 > Journal papers
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