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Association of mortality with drug-coated devices in femoropopliteal artery based on the nationwide data
- Title
- Association of mortality with drug-coated devices in femoropopliteal artery based on the nationwide data
- Authors
- Choi, Hyunsook; Lee, Haine; Lee, Sang-Soo; Ahn, Jeonghoon; Joh, Jin Hyun; Lee, Moo-Yeol
- Ewha Authors
- 안정훈
- SCOPUS Author ID
- 안정훈
- Issue Date
- 2021
- Journal Title
- ANNALS OF SURGICAL TREATMENT AND RESEARCH
- ISSN
- 2288-6575
2288-6796
- Citation
- ANNALS OF SURGICAL TREATMENT AND RESEARCH vol. 101, no. 1, pp. 20 - 27
- Keywords
- Angioplasty; Mortality; Paclitaxel; Peripheral arterial occlusive disease; Stents
- Publisher
- KOREAN SURGICAL SOCIETY
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Purpose: Drug-coated devices have been widely accepted as one of the most promising therapies for femoropopliteal artery revascularization. A recent meta-analysis showed increased mortality in patients treated with drug-coated devices. We sought to examine the association between mortality and drug-coated devices after the treatment of the femoropopliteal artery based on the Korea national administrative claims data. Methods: In the National Health Insurance Service database from August 2015 to December 2017, we identified patients with femoropopliteal artery revascularization using percutaneous transluminal angioplasty (PTA), bare metal stents (BMS), drug-coated balloon (DCB), or drug-eluting stents (DES). Kaplan-Meier methods were used to estimate the survival among devices, and log-rank tests were used to evaluate differences between groups. Adjusted hazard ratios (aHRs) were computed using the inverse probability of treatment weightings (IPTW). Results: There were 1,724 patients (mean age, 70.9 +/- 10.7 years; male, 1,350 [78.3%]) included in the analysis. The median follow-up period was 552 days (interquartile range, 404-688 days). There was a difference in IPTW-adjusted mortality risk among device types (26.3% in PTA, 22.1% in BMS, 17.7% in DCB, and 17.8% in DES; P = 0.004). IPTW-adjusted Cox proportional hazard analysis showed that drug-coated devices were associated with decreased all-cause mortality risk (aHR, 0.70; 95% confidence interval, 0.58-0.86). Conclusion: Our real-world analysis showed that there was no evidence of increased all-cause mortality after femoropopliteal artery revascularization with drug-coated devices compared with non-drug-coated devices. [Ann Surg Treat Res 2021;101(1):20-27]
- DOI
- 10.4174/astr.2021.101.1.20
- Appears in Collections:
- 신산업융합대학 > 융합보건학과 > Journal papers
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