View : 417 Download: 0
Empirical assessment of biases in cerebrospinal fluid biomarkers of Alzheimer's disease: an umbrella review and re-analysis of data from meta-analyses
- Title
- Empirical assessment of biases in cerebrospinal fluid biomarkers of Alzheimer's disease: an umbrella review and re-analysis of data from meta-analyses
- Authors
- Jeong, D. Y.; Lee, J.; Kim, J. Y.; Lee, K. H.; Li, H.; Lee, J. Y.; Jeong, G. H.; Yoon, S.; Park, E. L.; Hong, S. H.; Kang, J. W.; Song, T-J; Leyhe, T.; Eisenhut, M.; Kronbichler, A.; Smith, L.; Solmi, M.; Stubbs, B.; Koyanagi, A.; Jacob, L.; Stickley, A.; Thompson, T.; Dragioti, E.; Oh, H.; Brunoni, A. R.; Carvalho, A. F.; Kim, M. S.; Yon, D. K.; Lee, S. W.; Yang, J. M.; Ghayda, R. A.; Shin, J., I; Fusar-Poli, P.
- Ewha Authors
- 송태진
- SCOPUS Author ID
- 송태진
- Issue Date
- 2021
- Journal Title
- EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
- ISSN
- 1128-3602
- Citation
- EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES vol. 25, no. 3, pp. 1536 - 1547
- Keywords
- Alzheimer's disease; CSF biomarkers; Meta-analysis; Umbrella review; Excess significance
- Publisher
- VERDUCI PUBLISHER
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- OBJECTIVE: Alzheimer's disease (AD) is a leading cause of years lived with disability in older age, and several cerebrospinal fluid (CSF) markers have been proposed in individual meta-analyses to be associated with AD but field-wide evaluation and scrutiny of the literature is not available. MATERIALS AND METHODS: We performed an umbrella review for the reported associations between CSF biomarkers and AD. Data from available meta-analyses were reanalyzed using both random and fixed effects models. We also estimated between-study heterogeneity, small-study effects, excess significance, and prediction interval. RESULTS: A total of 38 meta-analyses on CSF markers from 11 eligible articles were identified and reanalyzed. In 14 (36%) of the meta-analyses, the summary estimate and the results of the largest study showed non-concordant results in terms of statistical significance. Large heterogeneity (I-2=75%) was observed in 73% and smallstudy effects under Egger's test were shown in 28% of CSF biomarkers. CONCLUSIONS: Our results suggest that there is an excess of statistically significant results and significant biases in the literature of CSF biomarkers for AD. Therefore, the results of CSF biomarkers should be interpreted with caution.
- DOI
- 10.26355/eurrev_202102_24862
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML