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Endocrine-disrupting chemicals and infectious diseases: From endocrine disruption to immunosuppression
- Title
- Endocrine-disrupting chemicals and infectious diseases: From endocrine disruption to immunosuppression
- Authors
- Adegoke E.O.; Rahman M.S.; Park Y.-J.; Kim Y.J.; Pang M.-G.
- Ewha Authors
- 김영주
- SCOPUS Author ID
- 김영주
![scopus](/images/layout/icon2.png)
- Issue Date
- 2021
- Journal Title
- International Journal of Molecular Sciences
- ISSN
- 1661-6596
- Citation
- International Journal of Molecular Sciences vol. 22, no. 8
- Keywords
- Comorbid diseases; COVID-19; Endocrine disrupting chemicals; Immune dysfunction
- Publisher
- MDPI AG
- Indexed
- SCIE; SCOPUS
![scopus](/images/layout/scopus2.gif)
- Document Type
- Review
- Abstract
- Endocrine-disrupting chemicals (EDCs) are hormonally active compounds in the environment that interfere with the body’s endocrine system and consequently produce adverse health effects. Despite persistent public health concerns, EDCs remain important components of common consumer products, thus representing ubiquitous contaminants to humans. While scientific evidence confirmed their contribution to the severity of Influenza A virus (H1N1) in the animal model, their roles in susceptibility and clinical outcome of the coronavirus disease (COVID-19) cannot be underestimated. Since its emergence in late 2019, clinical reports on COVID-19 have confirmed that severe disease and death occur in persons aged ≥65 years and those with underlying comorbidities. Major comorbidities of COVID-19 include diabetes, obesity, cardiovascular disease, hypertension, cancer, and kidney and liver diseases. Meanwhile, long-term exposure to EDCs contributes significantly to the onset and progression of these comorbid diseases. Besides, EDCs play vital roles in the disruption of the body’s immune system. Here, we review the recent literature on the roles of EDCs in comorbidities contributing to COVID-19 mortality, impacts of EDCs on the immune system, and recent articles linking EDCs to COVID-19 risks. We also recommend methodologies that could be adopted to comprehensively study the role of EDCs in COVID-19 risk. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- DOI
- 10.3390/ijms22083939
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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