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Clinical Outcomes Following Letrozole Treatment according to Estrogen Receptor Expression in Postmenopausal Women: LETTER Study (KBCSG-006)
- Title
- Clinical Outcomes Following Letrozole Treatment according to Estrogen Receptor Expression in Postmenopausal Women: LETTER Study (KBCSG-006)
- Authors
- Ahn, Sung Gwe; Nam, Seok Jin; Ahn, Sei Hyun; Jung, Yongsik; Park, Heung Kyu; Lee, Soo Jung; Kang, Sung Soo; Han, Wonshik; Park, Kyong Hwa; Park, Yong Lai; Lee, Jihyoun; Youn, Hyun Jo; Kim, Jun Hyun; Yoo, Youngbum; Song, Jeong Yoon; Ko, Byung Kyun; Gwak, Geumhee; Chung, Min Sung; Kim, Sung Yong; Cho, Seo Heon; Kim, Doyil; Chang, Myung Chul; Moon, Byung In; Kim, Lee Su; Kim, Sei Joong; Park, Min Ho; Kim, Tae Hyun; Cho, Jihyoung; Lim, Cheol Wan; Bae, Young Tae; Gong, Gyungyub; Bae, Young Kyung; Lee, Ahwon; Jeong, Joon
- Ewha Authors
- 문병인
- SCOPUS Author ID
- 문병인
- Issue Date
- 2021
- Journal Title
- JOURNAL OF BREAST CANCER
- ISSN
- 1738-6756
2092-9900
- Citation
- JOURNAL OF BREAST CANCER vol. 24, no. 2, pp. 164 - 174
- Keywords
- Breast neoplasms; Letrozole; Postmenopause; Receptors, estrogen
- Publisher
- KOREAN BREAST CANCER SOC
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Purpose: In this trial, we investigated the efficacy and safety of adjuvant letrozole for hormone receptor (HR)-positive breast cancer. Here, we report the clinical outcome in postmenopausal women with HR-positive breast cancer treated with adjuvant letrozole according to estrogen receptor (ER) expression levels. Methods: In this multi-institutional, open-label, observational study, postmenopausal patients with HR-positive breast cancer received adjuvant letrozole (2.5 mg/daily) for 5 years unless they experienced disease progression or unacceptable toxicity or withdrew their consent. The patients were stratified into the following 3 groups according to ER expression levels using a modified Allred score (AS): low, intermediate, and high (AS 3-4, 5-6, and 7-8, respectively). ER expression was centrally reviewed. The primary objective was the 5-year disease-free survival (DFS) rate. Results: Between April 25, 2010, and February 5, 2014, 440 patients were enrolled. With a median follow-up of 62.0 months, the 5-year DFS rate in all patients was 94.2% (95% confidence interval [CI], 91.8-96.6). The 5-year DFS and recurrence-free survival (RFS) rates did not differ according to ER expression; the 5-year DFS rates were 94.3% and 94.1%in the low-to-intermediate and high expression groups, respectively (p = 0.6), and the corresponding 5-year RFS rates were 95.7% and 95.4%, respectively (p = 0.7). Furthermore, 25 patients discontinued letrozole because of drug toxicity. Conclusion: Treatment with adjuvant letrozole showed very favorable treatment outcomes and good tolerability among Korean postmenopausal women with ER-positive breast cancer, independent of ER expression.
- DOI
- 10.4048/jbc.2021.24.e17
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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