Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 조영주 | * |
dc.contributor.author | 김승정 | * |
dc.contributor.author | 류동열 | * |
dc.contributor.author | 김민혜 | * |
dc.date.accessioned | 2021-03-02T16:30:43Z | - |
dc.date.available | 2021-03-02T16:30:43Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 2213-2198 | * |
dc.identifier.issn | 2213-2201 | * |
dc.identifier.other | OAK-24662 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/257223 | - |
dc.description.abstract | BACKGROUND: Thus far, human leukocyte antigen (HLA)-B*58:01 has been recognized as the most important risk factor for allopurinol induced severe cutaneous adverse reactions (SCARs). OBJECTIVE: To determine the usefulness of prospective screening for the HLA-B*58:01 allele to identify Korean individuals at risk for SCARs induced by allopurinol treatment. METHODS: We prospectively enrolled 542 patients with chronic renal insufficiency (CRI) from 10 hospitals nationwide and performed DNA genotyping to determine whether they carried the HLA-B*58:01 allele. Of these, 503 HLA-B*58:01-negative patients (92.8% of total) were treated with allopurinol, and 39 HLA-B*58:01-positive patients (7.2%) were treated with febuxostat, an alternative drug. The patients then were followed up biweekly for 90 days using a telephone survey to monitor symptoms of adverse drug reactions, including SCARs. As a control, we used the historical incidence rate of allopurinol-induced SCARs in 4002 patients with CRI from the same hospitals who were enrolled retrospectively. RESULTS: Nineteen patients in the prospective cohort developed mild and transient adverse reactions but none showed allopurinol-induced SCARs. By contrast, we identified 38 patients with allopurinol-induced SCARs (0.95%) in the historical control. The difference in the incidence of allopurinol-induced SCARs between the prospective cohort and historical control was statistically significant (0% vs 0.95%, respectively; P = .029). CONCLUSIONS: The present study demonstrated the clinical usefulness of the HLA-B*58:01 screening test before allopurinol administration to prevent allopurinol-induced SCARs in patients with CRI. (C) 2018 American Academy of Allergy, Asthma & Immunology | * |
dc.language | English | * |
dc.publisher | ELSEVIER | * |
dc.subject | Allopurinol | * |
dc.subject | HLA-B*58:01 allele | * |
dc.subject | Drug hypersensitivity | * |
dc.subject | Renal insufficiency | * |
dc.subject | Chronic | * |
dc.title | Efficacy of the HLA-B*58:01 Screening Test in Preventing Allopurinol-Induced Severe Cutaneous Adverse Reactions in Patients with Chronic Renal Insufficiency-A Prospective Study | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 7 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1271 | * |
dc.relation.lastpage | 1276 | * |
dc.relation.journaltitle | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | * |
dc.identifier.doi | 10.1016/j.jaip.2018.12.012 | * |
dc.identifier.wosid | WOS:000463732500024 | * |
dc.identifier.scopusid | 2-s2.0-85059943172 | * |
dc.author.google | Park, Heung-Woo | * |
dc.author.google | Kim, Dong Ki | * |
dc.author.google | Kim, Sae-Hoon | * |
dc.author.google | Kim, Sejoong | * |
dc.author.google | Chae, Dong-Wan | * |
dc.author.google | Yang, Min-Suk | * |
dc.author.google | Oh, Yun Kyu | * |
dc.author.google | Lee, Jung Pyo | * |
dc.author.google | Jung, Jae-Woo | * |
dc.author.google | Shin, Jungho | * |
dc.author.google | Hwang, Jin Ho | * |
dc.author.google | Kang, Min-Gyu | * |
dc.author.google | Kim, Sun Moon | * |
dc.author.google | Kwon, Soon Kil | * |
dc.author.google | Kim, Hye-Young | * |
dc.author.google | Kim, Min-Hye | * |
dc.author.google | Kim, Seung-Jung | * |
dc.author.google | Ryu, Dong-Ryeol | * |
dc.author.google | Cho, Young-Joo | * |
dc.author.google | Jee, Young-Koo | * |
dc.author.google | Kim, So Mi | * |
dc.author.google | Lee, Eun Kyoung | * |
dc.author.google | Kim, Ju-Young | * |
dc.author.google | Cho, Hyun Seop | * |
dc.author.google | Jeong, Yi Yeong | * |
dc.author.google | Kim, Sang-Heon | * |
dc.author.google | Jun, Jae-Bum | * |
dc.author.google | Park, Joon-Sung | * |
dc.author.google | Kim, Gheun-Ho | * |
dc.author.google | Kim, Sujeong | * |
dc.author.google | Jung, Hee-Yeon | * |
dc.author.google | Lee, Jong-Myung | * |
dc.contributor.scopusid | 조영주(55472202600;56657140200) | * |
dc.contributor.scopusid | 김승정(8619054500) | * |
dc.contributor.scopusid | 류동열(7103144218;56997547400;56669926200) | * |
dc.contributor.scopusid | 김민혜(58045929900) | * |
dc.date.modifydate | 20240419142141 | * |