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Porcine Tracheal Mucosa-Derived Decellularized Patch to Prevent Septal Perforation in a Rabbit Model
- Title
- Porcine Tracheal Mucosa-Derived Decellularized Patch to Prevent Septal Perforation in a Rabbit Model
- Authors
- Kim, So Jeong; Jung, Soo Yeon; Lee, Min Ji; Bae, Jung Ho; Kim, Han Su
- Ewha Authors
- 김한수; 배정호; 정수연; 김소정
- SCOPUS Author ID
- 김한수; 배정호; 정수연; 김소정
- Issue Date
- 2021
- Journal Title
- AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
- ISSN
- 1945-8924
1945-8932
- Citation
- AMERICAN JOURNAL OF RHINOLOGY & ALLERGY vol. 35, no. 4, pp. 417 - 425
- Keywords
- nasal septum; nasal septal perforation; nasal mucosa; xenograft; tissue scaffold
- Publisher
- SAGE PUBLICATIONS INC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background Nasal septal perforation is caused by bilateral septal mucosal injuries resulting from nasal trauma and septal surgeries. Previous studies have reported that biocompatible materials may be effective for repairing nasal septal perforations. However, they were primarily used for treatment; no study has investigated their use for prevention of nasal septal perforation. Objective To determine whether porcine tracheal mucosa-derived decellularized patch can prevent the progression of nasal mucosa injuries to septal perforations. Methods Bilateral nasal septal mucosal defects were surgically induced in 36 rabbits. Silastic sheets were applied bilaterally in all rabbits, and decellularized mucosal patch was applied unilaterally (n = 12) or bilaterally (n = 12) at the defect site in the respective experimental groups. Between 1 and 8 weeks postoperatively, the animals were sacrificed, and their nasal septa were completely removed. The excised septa were examined macroscopically and microscopically (histopathological examinations). Moreover, glycosaminoglycan (GAG) estimations of the septa were performed to evaluate mucosal regeneration and mechanical properties. Results Septal perforations occurred in 5 animals in the control group (5/12; 42%), 1 in the unilateral group (1/12; 9%), and in none in the bilateral group. Compared with the control group, the experimental groups showed significantly different mucosal and cartilage regeneration. Conclusion Decellularized porcine tracheal mucosa can prevent mucosal defects from progressing to septal perforation, promote the repair of mucosal defects, and protect the nasal cartilage.
- DOI
- 10.1177/1945892420961971
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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