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Diagnostic and Therapeutic Implications of microRNAs in Non-Small Cell Lung Cancer
- Title
- Diagnostic and Therapeutic Implications of microRNAs in Non-Small Cell Lung Cancer
- Authors
- Ahn, Young-Ho; Ko, Yoon Ho
- Ewha Authors
- 안영호
- SCOPUS Author ID
- 안영호
- Issue Date
- 2020
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- ISSN
- 1422-0067
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES vol. 21, no. 22
- Keywords
- microRNA; non-small cell lung cancer; diagnosis; prognosis
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- microRNAs (miRNAs), endogenous suppressors of target mRNAs, are deeply involved in every step of non-small cell lung cancer (NSCLC) development, from tumor initiation to progression and metastasis. They play roles in cell proliferation, apoptosis, angiogenesis, epithelial-to-mesenchymal transition, migration, invasion, and metastatic colonization, as well as immunosuppression. Due to their versatility, numerous attempts have been made to use miRNAs for clinical applications. miRNAs can be used as cancer subtype classifiers, diagnostic markers, drug-response predictors, prognostic markers, and therapeutic targets in NSCLC. Many challenges remain ahead of their actual clinical application; however, when achieved, the use of miRNAs in the clinic is expected to enable great progress in the diagnosis and treatment of patients with NSCLC.
- DOI
- 10.3390/ijms21228782
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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ijms-21-08782.pdf(670.06 kB)
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