Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임원정 | * |
dc.contributor.author | 김수인 | * |
dc.contributor.author | 김선영 | * |
dc.date.accessioned | 2021-02-04T16:31:01Z | - |
dc.date.available | 2021-02-04T16:31:01Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 0278-5846 | * |
dc.identifier.other | OAK-28650 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/256852 | - |
dc.description.abstract | We aimed to investigate the associations between genetic variants of the norepinephrine transporter gene (NET, also known as SLC6A2) and diagnosis of bipolar I disorder. In addition, we examined the relationship between the genetic variants and manic and psychotic symptoms in patients with bipolar I disorder. The three SNPs rs28386840, rs2242446, and rs5569 were genotyped in 326 patients: patients with bipolar I disorder (n = 160) and a control group (n = 166). Subsequently, multivariate logistic regression analysis adjusting for age and sex was conducted to identify independent influences of the SNPs on diagnosis of bipolar I disorder. A possible association between manic and psychotic symptoms and variants of SLC6A2 was also investigated in patients with bipolar I disorder. The rs28836840 SNP in the 5’-UTR of SLC6A2 was significantly associated with bipolar I disorder and with severity of manic and psychotic symptoms in this disorder. Individuals carrying a T allele in the rs28836840 SNP were likely to have a lower risk of bipolar I disorder or lower severity of manic and psychotic symptoms in patients with bipolar I disorder (bipolar I disorder diagnosis: OR = 0.643, 95% Cl = 0.468–0.883, p = 0.006; manic symptoms: β = −2.457, 95% Cl = −4.674 ~ −0.239, p = 0.031; psychotic symptoms: β = −2.501, 95% Cl = −4.700 ~ −0.301, p = 0.027). For the rs2242446 and rs5569 SNPs, there were no significant differences between patients with bipolar I disorder and those without. Our results revealed associations of the rs28386840 SNP with bipolar I disorder diagnosis and with severity of manic and psychotic symptoms. However, the findings reported here require replication in larger samples and various ethnic groups. © 2020 Elsevier Inc. | * |
dc.language | English | * |
dc.publisher | Elsevier Inc. | * |
dc.subject | Bipolar I disorder | * |
dc.subject | Manic symptom | * |
dc.subject | NET | * |
dc.subject | Psychotic symptom | * |
dc.subject | SLC6A2 | * |
dc.title | Association between genetic variants of the norepinephrine transporter gene (SLC6A2) and bipolar I disorder | * |
dc.type | Article | * |
dc.relation.volume | 107 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Progress in Neuro-Psychopharmacology and Biological Psychiatry | * |
dc.identifier.doi | 10.1016/j.pnpbp.2020.110227 | * |
dc.identifier.wosid | WOS:000617280700010 | * |
dc.identifier.scopusid | 2-s2.0-85098163365 | * |
dc.author.google | Kim S.-Y. | * |
dc.author.google | Kim H.-N. | * |
dc.author.google | Jeon S.W. | * |
dc.author.google | Lim W.-J. | * |
dc.author.google | Kim S.I. | * |
dc.author.google | Lee Y.J. | * |
dc.author.google | Kim S.Y. | * |
dc.author.google | Kim Y.-K. | * |
dc.contributor.scopusid | 임원정(8404516800) | * |
dc.contributor.scopusid | 김수인(54787809400) | * |
dc.contributor.scopusid | 김선영(57200860491) | * |
dc.date.modifydate | 20240123101016 | * |