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Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice

Title
Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice
Authors
Lee S.-H.Cho S.-Y.Yoon Y.Park C.Sohn J.Jeong J.-J.Jeon B.-N.Jang M.An C.Lee S.Kim Y.Y.Kim G.Kim S.Kim Y.Lee G.B.Lee E.J.Kim S.G.Kim H.S.Kim H.Yang H.-S.Chung H.Moon M.H.Nam M.H.Kwon J.Y.Won S.Park J.-S.Weinstock G.M.Lee C.Yoon K.W.Park H.
Ewha Authors
Charles Lee
SCOPUS Author ID
Charles Leescopusscopus
Issue Date
2021
Journal Title
Nature Microbiology
ISSN
2058-5276JCR Link
Citation
Nature Microbiology vol. 6, no. 3, pp. 277 - 288
Publisher
Nature Research
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
The gut microbiome can influence the development of tumours and the efficacy of cancer therapeutics1–5; however, the multi-omics characteristics of antitumour bacterial strains have not been fully elucidated. In this study, we integrated metagenomics, genomics and transcriptomics of bacteria, and analyses of mouse intestinal transcriptome and serum metabolome data to reveal an additional mechanism by which bacteria determine the efficacy of cancer therapeutics. In gut microbiome analyses of 96 samples from patients with non-small-cell lung cancer, Bifidobacterium bifidum was abundant in patients responsive to therapy. However, when we treated syngeneic mouse tumours with commercial strains of B. bifidum to establish relevance for potential therapeutic uses, only specific B. bifidum strains reduced tumour burden synergistically with PD-1 blockade or oxaliplatin treatment by eliciting an antitumour host immune response. In mice, these strains induced tuning of the immunological background by potentiating the production of interferon-γ, probably through the enhanced biosynthesis of immune-stimulating molecules and metabolites. © 2021, The Author(s), under exclusive licence to Springer Nature Limited.
DOI
10.1038/s41564-020-00831-6
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자연과학대학 > 생명과학전공 > Journal papers
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