Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신상훈 | * |
dc.date.accessioned | 2021-01-28T16:30:02Z | - |
dc.date.available | 2021-01-28T16:30:02Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1934-5925 | * |
dc.identifier.other | OAK-28759 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/256221 | - |
dc.description.abstract | Background: The current study aimed to examine the independent prognostic value of whole-heart atherosclerosis progression by serial coronary computed tomography angiography (CCTA) for major adverse cardiovascular events (MACE). Methods: The multi-center PARADIGM study includes patients undergoing serial CCTA for symptomatic reasons, >2 years apart. Whole-heart atherosclerosis was characterized on a segmental level, with co-registration of baseline and follow-up CCTA, and summed to per-patient level. The independent prognostic significance of atherosclerosis progression for MACE (non-fatal myocardial infarction [MI], death, unplanned coronary revascularization) was examined. Patients experiencing interval MACE were not omitted. Results: The study population comprised 1166 patients (age 60.5 +/- 9.5 years, 54.7% male) who experienced 139 MACE events during 8.2 (IQR 6.2, 9.5) years of follow up (15 death, 5 non-fatal MI, 119 unplanned revascularizations). Whole-heart percent atheroma volume (PAV) increased from 2.32% at baseline to 4.04% at follow-up. Adjusted for baseline PAV, the annualized increase in PAV was independently associated with MACE: OR 1.23 (95% CI 1.08, 1.39) per 1 standard deviation increase, which was consistent in multiple subpopulations. When categorized by composition, only non-calcified plaque progression associated independently with MACE, while calcified plaque did not. Restricting to patients without events before follow-up CCTA, those with future MACE showed an annualized increase in PAV of 0.93% (IQR 0.34, 1.96) vs 0.32% (IQR 0.02, 0.90), P < 0.001. Conclusions: Whole-heart atherosclerosis progression examined by serial CCTA is independently associated with MACE, with a prognostic threshold of 1.0% increase in PAV per year. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCIENCE INC | * |
dc.subject | Coronary artery disease | * |
dc.subject | Plaque progression | * |
dc.subject | Coronary CTA | * |
dc.subject | Risk stratification | * |
dc.title | Progression of whole-heart Atherosclerosis by coronary CT and major adverse cardiovascular events | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 15 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 322 | * |
dc.relation.lastpage | 330 | * |
dc.relation.journaltitle | JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY | * |
dc.identifier.doi | 10.1016/j.jcct.2020.12.007 | * |
dc.identifier.wosid | WOS:000669573300007 | * |
dc.identifier.scopusid | 2-s2.0-85099478733 | * |
dc.author.google | van Rosendael, Alexander R. | * |
dc.author.google | Lin, Fay Y. | * |
dc.author.google | van den Hoogen, Inge J. | * |
dc.author.google | Ma, Xiaoyue | * |
dc.author.google | Gianni, Umberto | * |
dc.author.google | Alawamlh, Omar Al Hussein | * |
dc.author.google | Al'Aref, Subhi J. | * |
dc.author.google | Pena, Jessica M. | * |
dc.author.google | Andreini, Daniele | * |
dc.author.google | Budoff, Matthew J. | * |
dc.author.google | Cademartiri, Filippo | * |
dc.author.google | Chinnaiyan, Kavitha | * |
dc.author.google | Choi, Jung Hyun | * |
dc.author.google | Conte, Edoardo | * |
dc.author.google | Marques, Hugo | * |
dc.author.google | Goncalves, Pedro de Araujo | * |
dc.author.google | Gottlieb, Ilan | * |
dc.author.google | Hadamitzky, Martin | * |
dc.author.google | Leipsic, Jonathon | * |
dc.author.google | Maffei, Erica | * |
dc.author.google | Pontone, Gianluca | * |
dc.author.google | Raff, Gilbert L. | * |
dc.author.google | Shin, Sanghoon | * |
dc.author.google | Kim, Yong-Jin | * |
dc.author.google | Lee, Byoung Kwon | * |
dc.author.google | Chun, Eun Ju | * |
dc.author.google | Sung, Ji Min | * |
dc.author.google | Lee, Sang-Eun | * |
dc.author.google | Han, Donghee | * |
dc.author.google | Berman, Daniel S. | * |
dc.author.google | Virmani, Renu | * |
dc.author.google | Samady, Habib | * |
dc.author.google | Stone, Peter | * |
dc.author.google | Narula, Jagat | * |
dc.author.google | Bax, Jeroen J. | * |
dc.author.google | Shaw, Leslee J. | * |
dc.author.google | Min, James K. | * |
dc.author.google | Chang, Hyuk-Jae | * |
dc.contributor.scopusid | 신상훈(7403646689;27868133100) | * |
dc.date.modifydate | 20240426130307 | * |