Immediate Postoperative Angiographic Stagnation of Contrast Media and T2-Weighted Magnetic Resonance Imaging Features within Aneurysmal Sac Are Associated with Early Regression of Large or Giant Aneurysm After Flow Diversion Only

Abstract

BACKGROUND: We hypothesized that the immediate postoperative imaging features would be associated with early regression of flow-diverted aneurysms. We compared the imaging features from digital subtraction angiography and spin echo T2-weighted magnetic resonance imaging between those with early total regression and partial regression. METHODS: A total of 30 consecutive patients with large and giant aneurysms were treated with pipeline embolization devices and divided into 2 groups according to the follow-up angiographic findings at 3e6 months. Of the 30 patients, 20 had had total or near total regression and 10 had had partial regression of the aneurysmal sac. The baseline characteristics, percent area of stagnated iodine contrast agent on anteroposterior and lateral angiographic views just after installation of the pipeline device, and median, minimal, and 10-percentile signal intensity of the aneurysmal sac on T2-weighted spin echo images 1 day after the procedure were compared between the 2 groups. RESULTS: A comparison of the demographic data between the 2 groups showed no significant differences. The volume of the treated aneurysmal sac also did not differ significantly (2559.28 +/- 3021.45 mm(3) vs. 2551.76 +/- 6550.58 mm(3); P = 0.455). The total or near total regression group had a larger percent area of iodine stagnation on the lateral angiographic view compared with the partial regression group (52.26% vs. 23.35%; P = 0.002). The median, minimal, and 10-percentile signal intensity of the volume of interest were higher in the total or near total regression group than in the partial regression group (1.29 vs. 0.93 [P = 0.025]; 0.07 vs. 0.00 [P = 0.042]; 0.57 vs. 0.24 [P = 0.005]). CONCLUSIONS: The percent area of contrast media stagnation on lateral angiograms and the median, minimal, and 10th-percentile signal intensity of the volume of interest of treated aneurysmal sacs on T2-weighted images can be used to predict early regression of aneurysmal sacs.