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Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention

Title
Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention
Authors
Rahman, Md. AtaurRahman, MD. HasanurHossain, Md. ShahadatBiswas, ParthaIslam, RokibulUddin, Md JamalRahman, Md. HabiburRhim, Hyewhon
Ewha Authors
Md Jamal Uddin
Issue Date
2020
Journal Title
BIOMEDICINES
ISSN
2227-9059JCR Link
Citation
BIOMEDICINES vol. 8, no. 11
Keywords
autophagycancerphytochemicalnatural compoundtreatment
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Autophagy is a vacuolar, lysosomal degradation pathway for injured and damaged protein molecules and organelles in eukaryotic cells, which is controlled by nutrients and stress responses. Dysregulation of cellular autophagy may lead to various diseases such as neurodegenerative disease, obesity, cardiovascular disease, diabetes, and malignancies. Recently, natural compounds have come to attention for being able to modulate the autophagy pathway in cancer prevention, although the prospective role of autophagy in cancer treatment is very complex and not yet clearly elucidated. Numerous synthetic chemicals have been identified that modulate autophagy and are favorable candidates for cancer treatment, but they have adverse side effects. Therefore, different phytochemicals, which include natural compounds and their derivatives, have attracted significant attention for use as autophagy modulators in cancer treatment with minimal side effects. In the current review, we discuss the promising role of natural compounds in modulating the autophagy pathway to control and prevent cancer, and provide possible therapeutic options.
DOI
10.3390/biomedicines8110517
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연구기관 > 약학연구소 > Journal papers
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