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Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Title
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
Authors
Bailey M.H.Meyerson W.U.Dursi L.J.Gonzalez-Perez A.Gordenin D.A.Gossage J.Gotoh K.Govindan R.Grabau D.Graham J.S.Grant R.C.Green A.R.Green E.Greger L.Grehan N.Grimaldi S.Grimmond S.M.Grossman R.L.Grundhoff A.Gundem G.Guo Q.Gupta M.Gupta S.Gut M.Göke J.Ha G.Haake A.Haan D.Haas S.Haase K.Haber J.E.Habermann N.Haider S.Hama N.Hamdy F.C.Hamilton A.Hamilton M.P.Han L.Hanna G.B.Hansmann M.Haradhvala N.J.Harismendy O.Harliwong I.Harmanci A.O.Harrington E.Hasegawa T.Hawkins S.Hayami S.Hayashi S.Hayes D.N.Hayes S.J.Hayward N.K.Hazell S.He Y.Heath A.P.Heath S.C.Hedley D.Hegde A.M.Heiman D.I.Heins Z.Heisler L.E.Hellstrom-Lindberg E.Helmy M.Heo S.G.Hepperla A.J.Heredia-Genestar J.M.Herrmann C.Hersey P.Hilmarsdottir H.Hirano S.Hiraoka N.Hoadley K.A.Hobolth A.Hodzic E.Hoell J.I.Hoffmann S.Hofmann O.Holbrook A.Holik A.Z.Hollingsworth M.A.Holmes O.Holt R.A.Hong C.Hong E.P.Hong J.H.Hooijer G.K.Hornshøj H.Hosoda F.Hou Y.Hovestadt V.Howat W.Hoyle A.P.Hruban R.H.Hu J.Hua X.Huang K.-L.Huang M.Huang M.N.Huber W.Hudson T.J.Hummel M.Hung J.A.Huntsman D.Hupp T.R.Huse J.Huska M.R.Hübschmann D.Iacobuzio-Donahue C.A.Imbusch C.D.Imielinski M.Imoto S.Isaacs W.B.Isaev K.Ishikawa S.Iskar M.Islam S.M.A.Ittmann M.Ivkovic S.Izarzugaza J.M.G.Jacquemier J.Jakrot V.Jamieson N.B.Jang G.H.Jang S.J.Jayaseelan J.C.Jayasinghe R.Jefferys S.R.Jegalian K.Jennings J.L.Jeon S.-H.Jerman L.Ji Y.Jiao W.Johansson P.A.Johns A.L.Johns J.Johnson R.Johnson T.A.Jolly C.Joly Y.Jonasson J.G.Jones C.D.Jones D.T.W.Jones N.Jones S.J.M.Jonkers J.Ju Y.S.Juhl H.Juul M.Juul R.I.Juul S.Kabbe R.Kahles A.Kahraman A.Kaiser V.B.Kakavand H.Kalimuthu S.von Kalle C.Kang K.J.Karaszi K.Karlan B.Karlic R.Karsch D.Kassahn K.S.Katai H.Matthew T.J.Matthews L.Mayer E.Mayes S.Mayo M.Mbabaali F.McCune K.McDermott U.McGillivray P.D.McPherson J.D.McPherson J.R.McPherson T.A.Meier S.R.Meng A.Meng S.Merrett N.D.Merson S.Meyerson M.Mieczkowski P.A.Mihaiescu G.L.Mijalkovic S.Mijalkovic-Lazic A.M.Mikkelsen T.Milella M.Mileshkin L.Miller C.A.Miller 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Ewha Authors
김형래
SCOPUS Author ID
김형래scopus
Issue Date
2020
Journal Title
Nature Communications
ISSN
2041-1723JCR Link
Citation
Nature Communications vol. 11, no. 1
Publisher
Nature Research
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts. © 2020, The Author(s).
DOI
10.1038/s41467-020-18151-y
Appears in Collections:
의과대학 > 의학과 > Journal papers
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