Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김규보 | * |
dc.date.accessioned | 2020-12-23T16:30:07Z | - |
dc.date.available | 2020-12-23T16:30:07Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 0284-186X | * |
dc.identifier.issn | 1651-226X | * |
dc.identifier.other | OAK-26562 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255784 | - |
dc.description.abstract | Background: For decades, conventional fractionated whole breast irradiation (CF-WBI) was used after breast conserving surgery (BCS). Pivotal phase-3 trials on hypofractionated-WBI (HF-WBI) showed its non-inferiority as compared to CF-WBI. However, younger patients are often not treated with HF-WBI. The aim of this multi-centre comparative study is to confirm the safety of HF-WBI in a real-life series of younger patients. Material and methods: Between 2010 and 2016, a total of 786 patients aged less than 60 years old with early-stage breast cancer were treated with postoperative WBI after BCS in three breast cancer centres: 340 underwent HF-WBI while 446 were treated with CF-WBI. Acute toxicity was evaluated at the end of WBI. Late toxicity was evaluated at 6, 12, 24 and 36 months. Results: At univariate logistic analysis, hypofractionation showed a significant protective effect in terms of acute oedema, acute wet desquamation, chronic oedema, chronic erythema/pigmentation and breast fibrosis. At multivariate logistic analysis, hypofractionation was an independent significant factor for acute oedema, acute wet desquamation, and chronic oedema. There were not differences in tumour-related outcomes. Conclusions: HF-WBI showed significantly improved outcomes in terms of acute skin oedema, wet desquamation and chronic skin oedema. HF-WBI after BCS should be strongly encouraged to replace CF-WBI independently of age. | * |
dc.language | English | * |
dc.publisher | TAYLOR & | * |
dc.publisher | FRANCIS LTD | * |
dc.title | Hypofractionated whole breast irradiation after conservative surgery for patients aged less than 60 years: a multi-centre comparative study | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 59 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 188 | * |
dc.relation.lastpage | 195 | * |
dc.relation.journaltitle | ACTA ONCOLOGICA | * |
dc.identifier.doi | 10.1080/0284186X.2019.1695061 | * |
dc.identifier.wosid | WOS:000498362900001 | * |
dc.identifier.scopusid | 2-s2.0-85075533240 | * |
dc.author.google | Meattini, Icro | * |
dc.author.google | Poortmans, Philip | * |
dc.author.google | Kirova, Youlia | * |
dc.author.google | Saieva, Calogero | * |
dc.author.google | Visani, Luca | * |
dc.author.google | Salvestrini, Viola | * |
dc.author.google | Kim, Jiyoung | * |
dc.author.google | Jung, Wonguen | * |
dc.author.google | Olmetto, Emanuela | * |
dc.author.google | Mariotti, Matteo | * |
dc.author.google | Desideri, Isacco | * |
dc.author.google | Fourquet, Alain | * |
dc.author.google | Livi, Lorenzo | * |
dc.author.google | Kim, Kyubo | * |
dc.contributor.scopusid | 김규보(8213302900) | * |
dc.date.modifydate | 20240222162403 | * |