Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상은 | - |
dc.date.accessioned | 2020-12-21T16:30:02Z | - |
dc.date.available | 2020-12-21T16:30:02Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1569-5794 | - |
dc.identifier.other | OAK-28346 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255737 | - |
dc.description.abstract | To determine whether the assessment of individual plaques is superior in predicting the progression to obstructive coronary artery disease (CAD) on serial coronary computed tomography angiography (CCTA) than per-patient assessment. From a multinational registry of 2252 patients who underwent serial CCTA at a ≥ 2-year inter-scan interval, patients with only non-obstructive lesions at baseline were enrolled. CCTA was quantitatively analyzed at both the per-patient and per-lesion level. Models predicting the development of an obstructive lesion at follow up using either the per-patient or per-lesion level CCTA measures were constructed and compared. From 1297 patients (mean age 60 ± 9 years, 43% men) enrolled, a total of 3218 non-obstructive lesions were identified at baseline. At follow-up (inter-scan interval: 3.8 ± 1.6 years), 76 lesions (2.4%, 60 patients) became obstructive, defined as > 50% diameter stenosis. The C-statistics of Model 1, adjusted only by clinical risk factors, was 0.684. The addition of per-patient level total plaque volume (PV) and the presence of high-risk plaque (HRP) features to Model 1 improved the C-statistics to 0.825 [95% confidence interval (CI) 0.823–0.827]. When per-lesion level PV and the presence of HRP were added to Model 1, the predictive value of the model improved the C-statistics to 0.895 [95% CI 0.893–0.897]. The model utilizing per-lesion level CCTA measures was superior to the model utilizing per-patient level CCTA measures in predicting the development of an obstructive lesion (p < 0.001). Lesion-level analysis of coronary atherosclerotic plaques with CCTA yielded better predictive power for the development of obstructive CAD than the simple quantification of total coronary atherosclerotic burden at a per-patient level. Clinical Trial Registration: ClinicalTrials.gov NCT0280341 © 2020, Springer Nature B.V. | - |
dc.language | English | - |
dc.publisher | Springer Science and Business Media B.V. | - |
dc.subject | Coronary artery atherosclerosis | - |
dc.subject | Coronary artery disease | - |
dc.subject | Coronary computed tomography angiography | - |
dc.subject | Statins | - |
dc.title | Per-lesion versus per-patient analysis of coronary artery disease in predicting the development of obstructive lesions: the Progression of AtheRosclerotic PlAque DetermIned by Computed TmoGraphic Angiography Imaging (PARADIGM) study | - |
dc.type | Article | - |
dc.relation.issue | 12 | - |
dc.relation.volume | 36 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2357 | - |
dc.relation.lastpage | 2364 | - |
dc.relation.journaltitle | International Journal of Cardiovascular Imaging | - |
dc.identifier.doi | 10.1007/s10554-020-01960-z | - |
dc.identifier.scopusid | 2-s2.0-85089248654 | - |
dc.author.google | Lee S.-E. | - |
dc.author.google | Sung J.M. | - |
dc.author.google | Andreini D. | - |
dc.author.google | Al-Mallah M.H. | - |
dc.author.google | Budoff M.J. | - |
dc.author.google | Cademartiri F. | - |
dc.author.google | Chinnaiyan K. | - |
dc.author.google | Choi J.H. | - |
dc.author.google | Chun E.J. | - |
dc.author.google | Conte E. | - |
dc.author.google | Gottlieb I. | - |
dc.author.google | Hadamitzky M. | - |
dc.author.google | Kim Y.J. | - |
dc.author.google | Lee B.K. | - |
dc.author.google | Leipsic J.A. | - |
dc.author.google | Maffei E. | - |
dc.author.google | Marques H. | - |
dc.author.google | de Araújo Gonçalves P. | - |
dc.author.google | Pontone G. | - |
dc.author.google | Shin S. | - |
dc.author.google | Stone P.H. | - |
dc.author.google | Samady H. | - |
dc.author.google | Virmani R. | - |
dc.author.google | Narula J. | - |
dc.author.google | Berman D.S. | - |
dc.author.google | Shaw L.J. | - |
dc.author.google | Bax J.J. | - |
dc.author.google | Lin F.Y. | - |
dc.author.google | Min J.K. | - |
dc.author.google | Chang H.-J. | - |
dc.contributor.scopusid | 이상은(57213176330) | - |
dc.date.modifydate | 20230208112553 | - |