Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김휘영 | * |
dc.date.accessioned | 2020-12-14T16:30:08Z | - |
dc.date.available | 2020-12-14T16:30:08Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 0017-5749 | * |
dc.identifier.issn | 1468-3288 | * |
dc.identifier.other | OAK-28296 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255715 | - |
dc.description.abstract | Objective Direct comparison of the clinical outcomes between nucleos(t)ide analogue (NA) discontinuation versus NA continuation has not been performed in patients with chronic hepatitis B who achieved HBsAg-seroclearance. Whether NA discontinuation was as safe as NA continuation after NA-induced surface antigen of HBV (HBsAg) seroclearance was investigated in the present study. Designs This multicentre study included 276 patients from 16 hospitals in Korea who achieved NA-induced HBsAg seroclearance: 131 (47.5%) discontinued NA treatment within 6 months after HBsAg seroclearance (NA discontinuation group) and 145 (52.5%) continued NA treatment (NA continuation group). Primary endpoint was HBsAg reversion and secondary endpoints included serum HBV DNA redetection and development of hepatocellular carcinoma (HCC). Results During follow-up (median=26.9 months, IQR=12.2-49.2 months), 10 patients (3.6%) experienced HBsAg reversion, 6 (2.2%) showed HBV DNA redetection and 8 (2.9%) developed HCC. Compared with NA continuation, NA discontinuation was not associated with HBsAg reversion in both univariable (HR=0.45, 95% CI=0.12 to 1.76, log-rank p=0.24) and multivariable analyses (adjusted HR=0.65, 95% CI=0.16 to 2.59, p=0.54). The cumulative probabilities of HBsAg reversion at 1, 3 and 5 years were 0.8%, 2.3% and 5.0% in the NA discontinuation group, and 1.5%, 6.3% and 8.4% in the NA continuation group, respectively. NA discontinuation was not associated with higher risk of either HBV redetection (HR=0.83, 95% CI=0.16 to 4.16, log-rank p=0.82) or HCC development (HR=0.53, 95% CI=0.12 to 2.23, log-rank p=0.38). Conclusion The discontinuation of NA was not associated with a higher risk of either HBsAg reversion, serum HBV DNA redetection or HCC development compared with NA continuation among patients who achieved HBsAg seroclearance with NA. | * |
dc.language | English | * |
dc.publisher | BMJ PUBLISHING GROUP | * |
dc.title | Discontinuation of nucleos(t)ide analogues is not associated with a higher risk of HBsAg seroreversion after antiviral-induced HBsAg seroclearance: a nationwide multicentre study | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 69 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2214 | * |
dc.relation.lastpage | 2222 | * |
dc.relation.journaltitle | GUT | * |
dc.identifier.doi | 10.1136/gutjnl-2019-320015 | * |
dc.identifier.wosid | WOS:000591525700017 | * |
dc.identifier.scopusid | 2-s2.0-85082521120 | * |
dc.author.google | Kim, Minseok Albert | * |
dc.author.google | Kim, Seung Up | * |
dc.author.google | Sinn, Dong Hyun | * |
dc.author.google | Jang, Jeong Won | * |
dc.author.google | Lim, Young-Suk | * |
dc.author.google | Ahn, Sang Hoon | * |
dc.author.google | Shim, Jae-Jun | * |
dc.author.google | Seo, Yeon Seok | * |
dc.author.google | Baek, Yang Hyun | * |
dc.author.google | Kim, Sang Gyune | * |
dc.author.google | Kim, Young Seok | * |
dc.author.google | Kim, Ji Hoon | * |
dc.author.google | Choe, Won Hyeok | * |
dc.author.google | Yim, Hyung Joon | * |
dc.author.google | Lee, Hyun Woong | * |
dc.author.google | Kwon, Jung Hyun | * |
dc.author.google | Lee, Sung Won | * |
dc.author.google | Jang, Jae Young | * |
dc.author.google | Kim, Hwi Young | * |
dc.author.google | Park, Yewan | * |
dc.author.google | Kim, Gi-Ae | * |
dc.author.google | Yang, Hyun | * |
dc.author.google | Lee, Han Ah | * |
dc.author.google | Koh, Myeongseok | * |
dc.author.google | Lee, Young-Sun | * |
dc.author.google | Kim, Minkoo | * |
dc.author.google | Chang, Young | * |
dc.author.google | Kim, Yoon Jun | * |
dc.author.google | Yoon, Jung-Hwan | * |
dc.author.google | Zoulim, Fabien | * |
dc.author.google | Lee, Jeong-Hoon | * |
dc.contributor.scopusid | 김휘영(56493773500) | * |
dc.date.modifydate | 20240429140130 | * |