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Long non-coding RNAs as regulators of interactions between cancer-associated fibroblasts and cancer cells in the tumor microenvironment
- Title
- Long non-coding RNAs as regulators of interactions between cancer-associated fibroblasts and cancer cells in the tumor microenvironment
- Authors
- Ahn Y.-H.; Kim J.S.
- Ewha Authors
- 안영호
- SCOPUS Author ID
- 안영호
- Issue Date
- 2020
- Journal Title
- International Journal of Molecular Sciences
- ISSN
- 1661-6596
- Citation
- International Journal of Molecular Sciences vol. 21, no. 20, pp. 1 - 16
- Keywords
- Cancer-associated fibroblasts; Long non-coding RNAs; Tumor microenvironment
- Publisher
- MDPI AG
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Long non-coding RNAs (lncRNAs) regulate diverse physiological and pathological processes via post-transcriptional, post-translational, and epigenetic mechanisms. They are also involved in tumor initiation, progression, and metastasis by functioning as key players in the tumor microenvironment. Cancer-associated fibroblasts (CAFs) promote tumor initiation, progression, metastasis, drug resistance, and immunosuppression, which can be modulated by lncRNAs. LncRNAs regulate the intrinsic properties of CAFs or cancer cells intracellularly or function extracellularly through exosomal secretion. In-depth studies on the mechanisms of lncRNA functions will enable their clinical use as diagnosis/prognosis markers and therapeutic targets in cancer treatment. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- DOI
- 10.3390/ijms21207484
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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