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Association of Tooth Loss with New-Onset Parkinson's Disease: A Nationwide Population-Based Cohort Study

Title
Association of Tooth Loss with New-Onset Parkinson's Disease: A Nationwide Population-Based Cohort Study
Authors
Woo, Ho GeolChang, YoonkyungLee, Ji SungSong, Tae-Jin
Ewha Authors
송태진장윤경우호걸
SCOPUS Author ID
송태진scopus
Issue Date
2020
Journal Title
PARKINSONS DISEASE
ISSN
2090-8083JCR Link

2042-0080JCR Link
Citation
PARKINSONS DISEASE vol. 2020
Publisher
HINDAWI LTD
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Introduction. Tooth loss is associated with poor oral hygiene. During insufficient oral sanitation, focal infection and inflammation can occur and these reactions may induce systemic inflammation. Systemic inflammatory reaction may be related to the degeneration of dopamine neurons in the substantia nigra. We hypothesized that tooth loss is related to increased risk of new-onset Parkinson's disease. Methods. Between 2003 and 2006, we included 153,165 participants from the national health insurance system-health screening cohort in Korea. The incidence of new-onset Parkinson's disease was defined as International Classification of Diseases-10 code "G20," accompanying the prescription records for any anti-Parkinson's disease medication. Results. Approximately 19.9% of the included participants had periodontal disease. After a median duration of 10.4 years, 1,227 (0.8%) cases of new-onset Parkinson's disease were noted. The number of tooth loss was positively related to an increased risk of new-onset Parkinson's disease. Contrastingly, the frequency of tooth brushings and dental clinic visits for any causes as well as competent dental care were negatively related to the development of new-onset Parkinson's disease. In multivariable analysis, the number of tooth loss (>= 15) was positively related to new-onset Parkinson's disease development (hazard ratio: 1.38, 95% confidence interval (1.03-1.85), p=0.029, p for trend = 0.043) after adjusting variables. Conclusion. Our study demonstrated that the number of tooth loss was positively correlated with a higher risk of new-onset Parkinson's disease development in a longitudinal study setting. Increased number of tooth loss may be an important risk indicator of new-onset Parkinson's disease.
DOI
10.1155/2020/4760512
Appears in Collections:
의과대학 > 의학과 > Journal papers
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