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Incidence of oral anticoagulant interruption among stroke patients with atrial fibrillation and subsequent stroke

Title
Incidence of oral anticoagulant interruption among stroke patients with atrial fibrillation and subsequent stroke
Authors
Kim, J. -M.Park, K. -Y.Yu, I. -W.Song, T. -J.Kim, Y. -J.Kim, B. J.Heo, S. H.Jung, J. -M.Oh, K. -M.Kim, C. K.Yu, S.Park, J. -H.Choi, J. C.Park, M. -S.Kim, J. -T.Choi, K. -H.Hwang, Y. -H.Chung, J. -W.Bang, O. Y.Kim, G. -M.Seo, W. -K.
Ewha Authors
송태진
SCOPUS Author ID
송태진scopus
Issue Date
2020
Journal Title
EUROPEAN JOURNAL OF NEUROLOGY
ISSN
1351-5101JCR Link

1468-1331JCR Link
Citation
EUROPEAN JOURNAL OF NEUROLOGY vol. 27, no. 5, pp. 900 - 902
Keywords
atrial fibrillationischaemic strokeoral anticoagulant
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background and purpose We analyzed the incidence and causes of oral anticoagulant (OAC) cessation and subsequent stroke after OAC withdrawal in a cohort of Korean stroke patients with atrial fibrillation. Methods The Korean Atrial Fibrillation Evaluation Registry in Ischemic Stroke patients (K-ATTENTION) is a multicenter cohort study, merging stroke registries from 11 tertiary centers in Korea. The number of OAC interruption episodes and the reasons were reviewed from hospital records. Stroke after OAC withdrawal was defined when a patient experienced ischaemic stroke within 31 days after OAC withdrawal. Clinical variables were compared between patients who experienced stroke recurrence during OAC interruption and those who did not experience recurrence. Results Among 3213 stroke patients with atrial fibrillation, a total of 329 episodes of OAC interruption were detected in 229 patients after index stroke (mean age 72.9 +/- 8.3 years, 113 female patients). The most frequent reason for OAC withdrawal was poor compliance [103 episodes (31.3%)] followed by extracranial bleeding [96 episodes (29.2%)]. Stroke after OAC withdrawal was noted in 13 patients. Mean age, vascular risk factor profile and mean CHA(2)DS(2)-VASc score were not significantly different between patients with and without recurrent stroke. Conclusions A considerable number of stroke patients with atrial fibrillation experienced temporary interruption of OAC after index stroke, which was associated with stroke recurrence of 4.0 cases per 100 interruption episodes.
DOI
10.1111/ene.14175
Appears in Collections:
의과대학 > 의학과 > Journal papers
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