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Effects ofKCNMB2gene polymorphisms on ritodrine therapy outcomes in women with preterm labor

Title
Effects ofKCNMB2gene polymorphisms on ritodrine therapy outcomes in women with preterm labor
Authors
Yoon, Ha YoungPark, Jin YoungYee, JeongHwang, Han SungChung, Jee EunLee, Kyung EunKim, Young JuGwak, Hye Sun
Ewha Authors
김영주곽혜선
SCOPUS Author ID
김영주scopus; 곽혜선scopus
Issue Date
2020
Journal Title
PHARMACOGENETICS AND GENOMICS
ISSN
1744-6872JCR Link

1744-6880JCR Link
Citation
PHARMACOGENETICS AND GENOMICS vol. 30, no. 6, pp. 124 - 130
Keywords
adverse drug eventpreterm laborritodrinesingle nucleotide polymorphismtime to deliveryKCNMB2
Publisher
LIPPINCOTT WILLIAMS &

WILKINS
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Objective The present prospective follow-up study aimed to evaluate the effects ofKCNMB2gene polymorphisms on ritodrine efficacy and adverse drug events (ADEs) in patients with preterm labor. Methods A total of 163 preterm labor patients were included in this single-center study. Nine single nucleotide polymorphisms (SNPs) in theKCNMB2gene (rs10936979, rs7624046, rs7429015, rs7625907, rs6443559, rs9839376, rs9637454, rs11918114, and rs1382045) were assessed. The primary endpoint was time to delivery, and the secondary endpoint was ritodrine-induced ADEs. Results Patients with variant homozygotes of two SNPs (rs7624046 and rs9839376), which were in linkage disequilibrium, showed 2.06 [95% confidence interval (CI), 1.14-3.73] and 2.68 (95% CI, 1.16-6.20) times the hazard of time to delivery compared to wild-type allele carriers, respectively. Among demographic characteristics, gestational age at start of drug therapy and modified Bishop score were significant factors for time to delivery. Regarding safety outcomes, patients with variant homozygotes of rs7625907 had fewer ADEs compared to those with other genotypes (odds ratio, 0.32; 95% CI, 0.13-0.83). Conclusion This pharmacogenomic study suggests that ritodrine efficacy and ADEs are associated withKCNMB2gene polymorphisms in patients with preterm labor.
DOI
10.1097/FPC.0000000000000404
Appears in Collections:
의과대학 > 의학과 > Journal papers
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