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Selectivity in Photodynamic Action: Higher Activity of Mitochondria Targeting Photosensitizers in Cancer Cells

Title
Selectivity in Photodynamic Action: Higher Activity of Mitochondria Targeting Photosensitizers in Cancer Cells
Authors
Ucar, EsmaSeyen, OzlemLee, DayoungKim, GyoungmiYoon, JuyoungAkkaya, Engin U.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2019
Journal Title
CHEMPHOTOCHEM
ISSN
2367-0932JCR Link
Citation
CHEMPHOTOCHEM vol. 3, no. 3, pp. 129 - 132
Keywords
cytotoxicityorganellesphotodynamic therapyphotosensitizerssinglet oxygen
Publisher
WILEY-V C H VERLAG GMBH
Indexed
SCIE WOS
Document Type
Article
Abstract
Among the pathways for improving the practice of photodynamic therapy of cancer, increasing the selectivity of photodynamic action is an obvious choice. Considering the different characteristics of mitochondria in normal cells and cancer cells, we designed mitochondria-targeting photosensitizers. We now demonstrate for the first time that mitochondria-targeted photosensitizers by triphenylphosphonium (TPP) derivatization are more selective for cancer cells compared to normal cells, presumably due to the larger membrane potential of cancer-cell mitochondria allowing more efficient accumulation of the photosensitizer.
DOI
10.1002/cptc.201800231
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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