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Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface
- Title
- Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface
- Authors
- Lee, Seokwoo; Lee, Yun Mi; Lee, Hyun-Ji; Jeon, Hongjun; Lee, Hyukjin; Shin, Dongyun; Kim, Sanghee
- Ewha Authors
- 이혁진
- SCOPUS Author ID
- 이혁진
- Issue Date
- 2019
- Journal Title
- ASIAN JOURNAL OF ORGANIC CHEMISTRY
- ISSN
- 2193-5807
2193-5815
- Citation
- ASIAN JOURNAL OF ORGANIC CHEMISTRY vol. 8, no. 9, pp. 1713 - 1717
- Keywords
- Ceramide; Click chemistry; Liposomes; Membrane fusion; Triazole
- Publisher
- WILEY-V C H VERLAG GMBH
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu+. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.
- DOI
- 10.1002/ajoc.201900342
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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